ADHD desynchronizes brain activity during watching a distracted multi-talker conversation

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dc.contributor.author Salmi, Juha
dc.contributor.author Metwaly, Mostafa
dc.contributor.author Tohka, Jussi
dc.contributor.author Alho, Kimmo
dc.contributor.author Leppämäki, Sami
dc.contributor.author Tani, Pekka
dc.contributor.author Koski, Anniina
dc.contributor.author Vanderwal, Tamara
dc.contributor.author Laine, Matti
dc.date.accessioned 2020-08-07T10:04:04Z
dc.date.available 2020-08-07T10:04:04Z
dc.date.issued 2020-08-01
dc.identifier.citation Salmi , J , Metwaly , M , Tohka , J , Alho , K , Leppämäki , S , Tani , P , Koski , A , Vanderwal , T & Laine , M 2020 , ' ADHD desynchronizes brain activity during watching a distracted multi-talker conversation ' , NeuroImage , vol. 216 , 116352 . https://doi.org/10.1016/j.neuroimage.2019.116352
dc.identifier.other PURE: 128170153
dc.identifier.other PURE UUID: 1544fbe7-635f-4607-a202-a46c73439ef4
dc.identifier.other RIS: urn:231E6111D1623FB5C8FED00654314DE2
dc.identifier.other WOS: 000541142200016
dc.identifier.other ORCID: /0000-0001-8563-2792/work/78462724
dc.identifier.uri http://hdl.handle.net/10138/318196
dc.description.abstract Individuals with attention-deficit/hyperactivity disorder (ADHD) have difficulties navigating dynamic everyday situations that contain multiple sensory inputs that need to either be attended to or ignored. As conventional experimental tasks lack this type of everyday complexity, we administered a film-based multi-talker condition with auditory distractors in the background. ADHD-related aberrant brain responses to this naturalistic stimulus were identified using intersubject correlations (ISCs) in functional magnetic resonance imaging (fMRI) data collected from 51 adults with ADHD and 29 healthy controls. A novel permutation-based approach introducing studentized statistics and subject-wise voxel-level null-distributions revealed that several areas in cerebral attention networks and sensory cortices were desynchronized in participants with ADHD (n = 20) relative to healthy controls (n = 20). Specifically, desynchronization of the posterior parietal cortex occurred when irrelevant speech or music was presented in the background, but not when irrelevant white noise was presented, or when there were no distractors. We also show regionally distinct ISC signatures for inattention and impulsivity. Finally, post-scan recall of the film contents was associated with stronger ISCs in the default-mode network for the ADHD and in the dorsal attention network for healthy controls. The present study shows that ISCs can further our understanding of how a complex environment influences brain states in ADHD. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof NeuroImage
dc.rights cc_by_nc_nd
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ADHD
dc.subject Attention
dc.subject fMRI
dc.subject Distraction
dc.subject Intersubject correlation
dc.subject Naturalistic condition
dc.subject 515 Psychology
dc.subject 3124 Neurology and psychiatry
dc.title ADHD desynchronizes brain activity during watching a distracted multi-talker conversation en
dc.type Article
dc.contributor.organization Medicum
dc.contributor.organization Attention and Memory Networks Research Group
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Kimmo Alho
dc.contributor.organization HUS Psychiatry
dc.contributor.organization Department of Psychiatry
dc.contributor.organization Mind and Matter
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.neuroimage.2019.116352
dc.relation.issn 1053-8119
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion
dc.relation.funder SUOMEN AKATEMIA
dc.relation.funder SUOMEN AKATEMIA
dc.relation.grantnumber
dc.relation.grantnumber

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