Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna

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Constantinou , J K , Southam , A D , Kvist , J , Jones , M R , Viant , M R & Mirbahai , L 2020 , ' Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna ' , Scientific Reports , vol. 10 , no. 1 , 5576 . https://doi.org/10.1038/s41598-020-62476-z

Title: Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna
Author: Constantinou, Julia K.; Southam, Andrew D.; Kvist, Jouni; Jones, Martin R.; Viant, Mark R.; Mirbahai, Leda
Contributor: University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
Date: 2020-03-27
Language: eng
Number of pages: 15
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/318203
Abstract: Lipids play a significant role in regulation of health and disease. To enhance our understanding of the role of lipids in regulation of lifespan and healthspan additional studies are required. Here, UHPLC-MS/MS lipidomics was used to measure dynamic changes in lipid composition as a function of age and gender in genetically identical male and female Daphnia magna with different average lifespans. We demonstrate statistically significant age-related changes in triglycerides (TG), diglycerides (DG), phosphatidylcholine, phosphatidylethanolamine, ceramide and sphingomyelin lipid groups, for example, in males, 17.04% of TG lipid species decline with age whilst 37.86% increase in relative intensity with age. In females, 23.16% decrease and 25.31% increase in relative intensity with age. Most interestingly, the rate and direction of change can differ between genetically identical female and male Daphnia magna, which could be the cause and/or the consequence of the different average lifespans between the two genetically identical genders. This study provides a benchmark dataset to understand how lipids alter as a function of age in genetically identical female and male species with different average lifespan and ageing rate.
Subject: 1182 Biochemistry, cell and molecular biology
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