Epicardial transplantation of atrial appendage micrograft patch salvages myocardium after infarction

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Xie , Y , Lampinen , M , Takala , J , Sikorski , V , Soliymani , R , Tarkia , M , Lalowski , M , Mervaala , E , Kupari , M , Zheng , Z , Hu , S , Harjula , A & Kankuri , E 2020 , ' Epicardial transplantation of atrial appendage micrograft patch salvages myocardium after infarction ' , Journal of Heart and Lung Transplantation , vol. 39 , no. 7 , pp. 707-718 . https://doi.org/10.1016/j.healun.2020.03.023

Title: Epicardial transplantation of atrial appendage micrograft patch salvages myocardium after infarction
Author: Xie, Yanbo; Lampinen, Milla; Takala, Juuso; Sikorski, Vilbert; Soliymani, Rabah; Tarkia, Miikka; Lalowski, Maciej; Mervaala, Eero; Kupari, Markku; Zheng, Zhe; Hu, Shengshou; Harjula, Ari; Kankuri, Esko
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Department of Pharmacology
University of Helsinki, Department of Pharmacology
University of Helsinki, Department of Biochemistry and Developmental Biology
University of Helsinki, Department of Pharmacology
University of Helsinki, Department of Biochemistry and Developmental Biology
University of Helsinki, Eero Mervaala / Principal Investigator
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Esko Markus Kankuri / Principal Investigator
Date: 2020-07
Language: eng
Number of pages: 12
Belongs to series: Journal of Heart and Lung Transplantation
ISSN: 1053-2498
URI: http://hdl.handle.net/10138/318374
Abstract: BACKGROUND Ischemic heart disease remains the leading cause of mortality and morbidity worldwide despite improved possibilities in medical care. Alongside interventional therapies, such as coronary artery bypass grafting, adjuvant tissue-engineered and cell-based treatments can provide regenerative improvement. Unfortunately, most of these advanced approaches require multiple lengthy and costly preparation stages without delivering significant clinical benefits. METHODS We evaluated the effect of epicardially delivered minute pieces of atrial appendage tissue material, defined as atrial appendage micrografts (AAMs), in mouse myocardial infarction model. An extracellular matrix patch was used to cover and fix the AAMs onto the surface of the infarcted heart. RESULTS The matrix-covered AAMs salvaged the heart from infarction-induced loss of functional myocardium and attenuated scarring. Site-selective proteomics of injured ischemic and uninjured distal myocardium from AAMs-treated and untreated tissue sections revealed an increased expression of several cardiac regeneration-associated proteins (i.e. periostin, transglutaminases and glutathione peroxidases) as well as activation of pathways responsible for angio- and cardiogenesis in relation to AAMs therapy. CONCLUSIONS Epicardial delivery of AAMs encased in an extracellular matrix patch scaffold salvages functional cardiac tissue from ischemic injury and restricts fibrosis after myocardial infarction. Our results support the use of AAMs as tissue-based therapy adjuvants for salvaging the ischemic myocardium.
Subject: 3126 Surgery, anesthesiology, intensive care, radiology
cell therapy
myocardial infarction
heart failure
myocardial regeneration
atrial appendage
site-selective proteomics
HEART-FAILURE
STEM-CELLS
CARDIOMYOCYTES
REGENERATION
DISEASE
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