Does entry to center-based childcare affect gut microbial colonization in young infants?

Show simple item record Hermes, Gerben D. A. Eckermann, Henrik A. de Vos, Willem M. de Weerth, Carolina 2020-08-19T06:16:01Z 2020-08-19T06:16:01Z 2020-06-24
dc.identifier.citation Hermes , G D A , Eckermann , H A , de Vos , W M & de Weerth , C 2020 , ' Does entry to center-based childcare affect gut microbial colonization in young infants? ' , Scientific Reports , vol. 10 , no. 1 , 10235 .
dc.identifier.other PURE: 142575474
dc.identifier.other PURE UUID: 8544de1b-bf26-4c32-83fd-dd876b109b2e
dc.identifier.other WOS: 000546711400002
dc.description.abstract Entry to center-based childcare (CC) at three months of life can be an important challenge for infants as it includes major stressors such as long maternal separations and frequently changing caregivers. Stress and the new environment may in turn alter the composition of the gut microbiota with possible implications for future health outcomes. As part of an ongoing longitudinal study, we investigated whether CC, as compared to being cared for by the parents at home, alters the composition of the gut microbiota, while accounting for known covariates of the infant gut microbiota. Stool samples of infants who entered CC (n=49) and control infants (n=49) were obtained before and four weeks after CC entrance. Using Redundancy analysis, Random Forests and Bayesian linear models we found that infant gut microbiota was not affected in a uniform way by entry to CC. In line with the literature, breastfeeding, birth mode, age, and the presence of siblings were shown to significantly impact the microbial composition. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject BRAIN
dc.subject HEALTH
dc.subject CORTISOL
dc.subject BEHAVIOR
dc.subject STRESS
dc.subject SUCCESSION
dc.subject IMPUTATION
dc.subject BACTERIAL
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title Does entry to center-based childcare affect gut microbial colonization in young infants? en
dc.type Article
dc.contributor.organization Department of Bacteriology and Immunology
dc.contributor.organization Willem Meindert Vos de / Principal Investigator
dc.contributor.organization de Vos & Salonen group
dc.contributor.organization Research Programs Unit
dc.contributor.organization HUMI - Human Microbiome Research
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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