Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns

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http://hdl.handle.net/10138/318439

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Ämmälä , A-J , Vitikainen , E I K , Hovatta , I , Paavonen , J , Saarenpää-Heikkilä , O , Kylliäinen , A , Pölkki , P , Porkka-Heiskanen , T & Paunio , T 2020 , ' Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns ' , Scientific Reports , vol. 10 , no. 1 , 13986 . https://doi.org/10.1038/s41598-020-71000-2

Title: Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns
Author: Ämmälä, Antti-Jussi; Vitikainen, Emma I K; Hovatta, Iiris; Paavonen, Juulia; Saarenpää-Heikkilä, Outi; Kylliäinen, Anneli; Pölkki, Pirjo; Porkka-Heiskanen, Tarja; Paunio, Tiina
Contributor organization: Department of Psychiatry
HUS Psychiatry
Helsinki One Health (HOH)
Evolution, Sociality & Behaviour
Biosciences
Organismal and Evolutionary Biology Research Programme
Faculty of Biological and Environmental Sciences
Department of Psychology and Logopedics
Iiris Hovatta / Principal Investigator
Genetics
Neuroscience Center
SLEEPWELL Research Program
HUS Children and Adolescents
Clinicum
Lastenpsykiatria
Medicum
Tarja Stenberg / Principal Investigator
Department of Physiology
Mind and Matter
Date: 2020-08-19
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-020-71000-2
URI: http://hdl.handle.net/10138/318439
Abstract: Telomeres play an important role in maintaining chromosomal integrity.With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health‑related outcomes. Transgenerationaleffects have been implicated in newborns, with maternal stress, depression,and anxiety predicting shorter telomere length at birth, possibly reflecting the intrauterine growth environment. Previous studies, with relatively small sample sizes, have reported an effect of maternal stress, BMI, and depression during pregnancy on the LTL of newborns. Here, we attempted to replicate previous findings on prenatal stress and newborn LTL in a sample of 1405 infants using aqPCR‑based method.In addition, previous research has been expanded by studying the relationship between maternal sleep quality and LTL. Maternal prenatal stress, anxiety, depression, BMI, and self‑reported sleep quality were evaluated with self‑reported questionnaires.Despite sufficient power to detect similar or even considerably smaller effects than those previously reported in the literature,we were unable to replicate the previous correlation between maternal stress, anxiety, depression,or sleep with LTL. We discuss several possible reasons for the discrepancies between our findings and those previously described.
Subject: 3124 Neurology and psychiatry
3123 Gynaecology and paediatrics
BODY-MASS INDEX
ASSOCIATION
DISEASE
DEPRESSION
MORTALITY
HERITABILITY
METAANALYSIS
CORTISOL
QUALITY
ANXIETY
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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