Probabilistic tractography in the ventrolateral thalamic nucleus: cerebellar and pallidal connections

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http://hdl.handle.net/10138/318522

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Pelzer , E A , Pauls , K A M , Braun , N , Tittgemeyer , M & Timmermann , L 2020 , ' Probabilistic tractography in the ventrolateral thalamic nucleus: cerebellar and pallidal connections ' , Brain structure & function , vol. 225 , no. 5 , pp. 1685-1689 . https://doi.org/10.1007/s00429-020-02076-9

Title: Probabilistic tractography in the ventrolateral thalamic nucleus: cerebellar and pallidal connections
Author: Pelzer, Esther A.; Pauls, K. Amande M.; Braun, Nina; Tittgemeyer, Marc; Timmermann, Lars
Contributor: University of Helsinki, BioMag Laboratory
Date: 2020-06
Language: eng
Number of pages: 5
Belongs to series: Brain structure & function
ISSN: 1863-2661
URI: http://hdl.handle.net/10138/318522
Abstract: The ventrolateral thalamic nucleus (VL), as part of the ‘motor thalamus’, is main relay station of cerebellar and pallidal projections. It comprises anterior (VLa) and posterior (VLpd and VLpv) subnuclei. Though the fibre architecture of cerebellar and pallidal projections to of the VL nucleus has already been focus in a numerous amount of in vitro studies mainly in animals, probabilistic tractography now offers the possibility of an in vivo comparison in healthy humans. In this study we performed a (a) qualitative and (b) quantitative examination of VL-cerebellar and VL-pallidal pathways and compared the probability distributions between both projection fields in the VL after an (I) atlas-based and (II) manual-based segmentation procedure. Both procedures led to high congruent results of cerebellar and pallidal connectivity distributions: the maximum of pallidal projections was located in anterior and medial parts of the VL nucleus, whereas cerebellar connectivity was more located in lateral and posterior parts. The median connectivity for cerebellar connections in both approaches (manual and atlas-based segmentation) was VLa > VLpv > VLpd, whereas the pallidal median connectivity was VLa ~ VLpv > VLpd in the atlas-based approach and VLpv > VLa > VLpd in the manual approach.
Subject: 3112 Neurosciences
Ventrolateral thalamus
Basal ganglia
Cerebellum
Probabilistic tractography
Qualitative and quantitative analyses
VENTRALIS INTERMEDIUS NUCLEUS
MOTOR THALAMUS
STIMULATION
MONKEY
3124 Neurology and psychiatry
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