Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication—a retrospective study

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Weseslindtner , L , Hedman , L , Wang , Y , Strassl , R , Helanterä , I , Aberle , S W , Bond , G & Hedman , K 2020 , ' Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication—a retrospective study ' , Transplant International , vol. 33 , no. 5 , pp. 555-566 . https://doi.org/10.1111/tri.13584

Title: Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication—a retrospective study
Author: Weseslindtner, Lukas; Hedman, Lea; Wang, Yilin; Strassl, Robert; Helanterä, Ilkka; Aberle, Stephan W.; Bond, Gregor; Hedman, Klaus
Contributor: University of Helsinki, Department of Virology
University of Helsinki, Klaus Hedman / Principal Investigator
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUSLAB
Date: 2020-05
Language: eng
Number of pages: 12
Belongs to series: Transplant International
ISSN: 0934-0874
URI: http://hdl.handle.net/10138/318542
Abstract: In kidney transplant recipients (KTRs), BK polyomavirus (BKPyV) replication may progress to polyomavirus-associated nephropathy (PVAN). In this retrospective study, we assessed the chemokine CXCL10 in urine and blood samples consecutively acquired from 85 KTRs who displayed different stages of BKPyV replication and eventually developed PVAN. In parallel to progression toward PVAN, CXCL10 gradually increased in blood and urine, from baseline (prior to virus replication) to BKPyV DNAuria (median increase in blood: 42.15 pg/ml, P = 0.0156), from mere DNAuria to low- and high-level BKPyV DNAemia (median increase: 52.60 and 87.26 pg/ml, P = 0.0010 and P = 0.0002, respectively) and peaked with histologically confirmed PVAN (median increase: 145.00 pg/ml, P <0.0001). CXCL10 blood and urine levels significantly differed among KTRs with respect to simultaneous presence of human cytomegalovirus (P <0.001) as well as in relation to the clinical severity of respective BKPyV DNAemia episodes (P = 0.0195). CXCL-10 concentrations were particularly lower in KTRs in whom BKPyV DNAemia remained without clinical evidence for PVAN, as compared to individuals who displayed high decoy cell levels, decreased renal function and/or biopsy-proven PVAN (median blood concentration: 266.97 vs. 426.42 pg/ml, P = 0.0282). In conclusion, in KTRs CXCL10 rises in parallel to BKPyV replication and correlates with the gradual development of PVAN.
Subject: 3126 Surgery, anesthesiology, intensive care, radiology
BK virus
CXCL10
kidney transplantation
nephropathy
polyomavirus
RENAL-ALLOGRAFT RECIPIENTS
HUMAN CYTOMEGALOVIRUS REPLICATION
VIRUS NEPHROPATHY
IP-10
NONINVASIVE DIAGNOSIS
INFLAMMATION
REJECTION
DISEASE
CHEMOKINE
INFECTION
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