Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication—a retrospective study

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dc.contributor.author Weseslindtner, Lukas
dc.contributor.author Hedman, Lea
dc.contributor.author Wang, Yilin
dc.contributor.author Strassl, Robert
dc.contributor.author Helanterä, Ilkka
dc.contributor.author Aberle, Stephan W.
dc.contributor.author Bond, Gregor
dc.contributor.author Hedman, Klaus
dc.date.accessioned 2020-08-25T06:54:01Z
dc.date.available 2020-08-25T06:54:01Z
dc.date.issued 2020-05
dc.identifier.citation Weseslindtner , L , Hedman , L , Wang , Y , Strassl , R , Helanterä , I , Aberle , S W , Bond , G & Hedman , K 2020 , ' Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication—a retrospective study ' , Transplant International , vol. 33 , no. 5 , pp. 555-566 . https://doi.org/10.1111/tri.13584
dc.identifier.other PURE: 132787690
dc.identifier.other PURE UUID: 08294424-789c-4038-be7f-786310232042
dc.identifier.other RIS: urn:E8B0DD4B3967ACC73B330FD240E84580
dc.identifier.other WOS: 000513145900001
dc.identifier.other ORCID: /0000-0003-1779-7960/work/79516596
dc.identifier.uri http://hdl.handle.net/10138/318542
dc.description.abstract In kidney transplant recipients (KTRs), BK polyomavirus (BKPyV) replication may progress to polyomavirus-associated nephropathy (PVAN). In this retrospective study, we assessed the chemokine CXCL10 in urine and blood samples consecutively acquired from 85 KTRs who displayed different stages of BKPyV replication and eventually developed PVAN. In parallel to progression toward PVAN, CXCL10 gradually increased in blood and urine, from baseline (prior to virus replication) to BKPyV DNAuria (median increase in blood: 42.15 pg/ml, P = 0.0156), from mere DNAuria to low- and high-level BKPyV DNAemia (median increase: 52.60 and 87.26 pg/ml, P = 0.0010 and P = 0.0002, respectively) and peaked with histologically confirmed PVAN (median increase: 145.00 pg/ml, P <0.0001). CXCL10 blood and urine levels significantly differed among KTRs with respect to simultaneous presence of human cytomegalovirus (P <0.001) as well as in relation to the clinical severity of respective BKPyV DNAemia episodes (P = 0.0195). CXCL-10 concentrations were particularly lower in KTRs in whom BKPyV DNAemia remained without clinical evidence for PVAN, as compared to individuals who displayed high decoy cell levels, decreased renal function and/or biopsy-proven PVAN (median blood concentration: 266.97 vs. 426.42 pg/ml, P = 0.0282). In conclusion, in KTRs CXCL10 rises in parallel to BKPyV replication and correlates with the gradual development of PVAN. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof Transplant International
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject BK virus
dc.subject CXCL10
dc.subject kidney transplantation
dc.subject nephropathy
dc.subject polyomavirus
dc.subject RENAL-ALLOGRAFT RECIPIENTS
dc.subject HUMAN CYTOMEGALOVIRUS REPLICATION
dc.subject VIRUS NEPHROPATHY
dc.subject IP-10
dc.subject NONINVASIVE DIAGNOSIS
dc.subject INFLAMMATION
dc.subject REJECTION
dc.subject DISEASE
dc.subject CHEMOKINE
dc.subject INFECTION
dc.title Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication—a retrospective study en
dc.type Article
dc.contributor.organization Department of Virology
dc.contributor.organization University of Helsinki
dc.contributor.organization Klaus Hedman / Principal Investigator
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Nefrologian yksikkö
dc.contributor.organization IV kirurgian klinikka
dc.contributor.organization HUSLAB
dc.contributor.organization Virus infections and immunity
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/tri.13584
dc.relation.issn 0934-0874
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion

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