Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury: a multi-center pilot study

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dc.contributor.author Thelin, Eric P.
dc.contributor.author Raj, Rahul
dc.contributor.author Bellander, Bo-Michael
dc.contributor.author Nelson, David
dc.contributor.author Piippo-Karjalainen, Anna
dc.contributor.author Siironen, Jari
dc.contributor.author Tanskanen, Päivi
dc.contributor.author Hawryluk, Gregory
dc.contributor.author Hasen, Mohammed
dc.contributor.author Unger, Bertram
dc.contributor.author Zeiler, Frederick A.
dc.date.accessioned 2020-08-26T07:05:01Z
dc.date.available 2020-08-26T07:05:01Z
dc.date.issued 2020-10
dc.identifier.citation Thelin , E P , Raj , R , Bellander , B-M , Nelson , D , Piippo-Karjalainen , A , Siironen , J , Tanskanen , P , Hawryluk , G , Hasen , M , Unger , B & Zeiler , F A 2020 , ' Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury: a multi-center pilot study ' , Journal of Clinical Monitoring and Computing , vol. 34 , no. 5 , pp. 971-994 . https://doi.org/10.1007/s10877-019-00392-y
dc.identifier.other PURE: 127129071
dc.identifier.other PURE UUID: dcac2af7-864d-4621-9414-db9040ee8406
dc.identifier.other RIS: urn:E0428E35F8629668DA67DBBF56CF2F8D
dc.identifier.other RIS: Thelin2019
dc.identifier.other WOS: 000565873100001
dc.identifier.uri http://hdl.handle.net/10138/318579
dc.description.abstract Current accepted cerebrovascular reactivity indices suffer from the need of high frequency data capture and export for post-acquisition processing. The role for minute-by-minute data in cerebrovascular reactivity monitoring remains uncertain. The goal was to explore the statistical time-series relationships between intra-cranial pressure (ICP), mean arterial pressure (MAP) and pressure reactivity index (PRx) using both 10-s and minute data update frequency in TBI. Prospective data from 31 patients from 3 centers with moderate/severe TBI and high-frequency archived physiology were reviewed. Both 10-s by 10-s and minute-by-minute mean values were derived for ICP and MAP for each patient. Similarly, PRx was derived using 30 consecutive 10-s data points, updated every minute. While long-PRx (L-PRx) was derived via similar methodology using minute-by-minute data, with L-PRx derived using various window lengths (5, 10, 20, 30, 40, and 60 min; denoted L-PRx_5, etc.). Time-series autoregressive integrative moving average (ARIMA) and vector autoregressive integrative moving average (VARIMA) models were created to analyze the relationship of these parameters over time. ARIMA modelling, Granger causality testing and VARIMA impulse response function (IRF) plotting demonstrated that similar information is carried in minute mean ICP and MAP data, compared to 10-s mean slow-wave ICP and MAP data. Shorter window L-PRx variants, such as L-PRx_5, appear to have a similar ARIMA structure, have a linear association with PRx and display moderate-to-strong correlations (r ~ 0.700, p  en
dc.format.extent 24
dc.language.iso eng
dc.relation.ispartof Journal of Clinical Monitoring and Computing
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject Autoregulation
dc.subject Cerebrovascular reactivity
dc.subject Low-frequency
dc.subject TBI
dc.subject PERFUSION-PRESSURE
dc.subject LOWER LIMIT
dc.subject PART II
dc.subject AUTOREGULATION
dc.subject MICRODIALYSIS
dc.subject VALIDATION
dc.subject MANAGEMENT
dc.subject CHEMISTRY
dc.subject INDEXES
dc.title Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury: a multi-center pilot study en
dc.type Article
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization Neurokirurgian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Helsinki and Uusimaa Hospital District
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Anestesiologian yksikkö
dc.contributor.organization HUS Perioperative, Intensive Care and Pain Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s10877-019-00392-y
dc.relation.issn 1573-2614
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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