Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy

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http://hdl.handle.net/10138/318726

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Piippo , S , Viljanen , M , Savilahti , E & Kuitunen , M 2020 , ' Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy ' , Immunity, Inflammation and Disease , vol. 8 , no. 3 , pp. 423-433 . https://doi.org/10.1002/iid3.324

Title: Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy
Author: Piippo, Sonja; Viljanen, Mirva; Savilahti, Erkki; Kuitunen, Mikael
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
Date: 2020-09
Language: eng
Number of pages: 11
Belongs to series: Immunity, Inflammation and Disease
ISSN: 2050-4527
URI: http://hdl.handle.net/10138/318726
Abstract: Background The association between atopic sensitisation, atopic eczema (AE) and asthma is known, but distinct roles of allergies on long-term health are unestablished. Objective Evaluation of allergic symptoms and sensitisation in adolescents who in infancy had AE and verified cows' milk allergy (CMA) or AE and a negative CMA challenge, and controls. Methods Children with AE, with and without CMA, from a randomised controlled study in 1999-2001 examining the effect of probiotics on AE severity at older than 12 months of age, attended a follow-up visit at age 16 to 18, with age-matched controls. Data came from a questionnaire (ISAAC questionnaire), analysis of serum antigen-specific immunoglobulin Es (IgEs), and clinical evaluation. Group comparisons were carried out (chi(2)tests and logistic regression). Results Fifty-two patients with AE and CMA (AE/CMA+ group), 52 with AE and suspicion of CMA (AE/CMA- group), and 57 controls attended a study visit. IgE-mediated sensitisation was significantly more prevalent in the AE/CMA+ group vs the controls, for horse, cat, dog, egg white and wheat (P <.024 for all). For birch, timothy and mugwort (P <.008 for all), sensitisation was more prevalent in both the AE/CMA+ group and the AE/CMA- group vs controls. On the basis of questionnaire data the AE/CMA + group reported a significantly higher lifetime prevalence of wheezing (64% vs 35% and 32%;P = .001), noninfectious rhinitis (85% vs 62% and 56%;P = .004), and hay fever (77% vs 52% and 33%;P <.001) vs the AE/CMA- group and the control group, respectively. Conclusion and Clinical Relevance Patients with AE and CMA in infancy, as opposed to patients with AE only, or controls, report more allergic symptoms and exhibit more allergic sensitisation in adolescence. This indicates that CMA in infancy is an independent risk factor of allergic disease in adolescence.
Subject: adolescent
allergic rhinitis
asthma
atopic eczema
cows' milk allergy
specific IgE
FOOD ALLERGY
NATURAL-HISTORY
CLINICAL-COURSE
DERMATITIS
ASTHMA
BIRTH
CHILDREN
COHORT
MARCH
EGG
3121 General medicine, internal medicine and other clinical medicine
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