Automated cot-side tracking of functional brain age in preterm infants

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http://hdl.handle.net/10138/318727

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Stevenson , N J , Oberdorfer , L , Tataranno , M-L , Breakspear , M , Colditz , P B , de Vries , L S , Benders , M J N L , Klebermass-Schrehof , K , Vanhatalo , S & Roberts , J A 2020 , ' Automated cot-side tracking of functional brain age in preterm infants ' , Annals of Clinical and Translational Neurology , vol. 7 , no. 6 , pp. 891-902 . https://doi.org/10.1002/acn3.51043

Title: Automated cot-side tracking of functional brain age in preterm infants
Author: Stevenson, Nathan J.; Oberdorfer, Lisa; Tataranno, Maria-Luisa; Breakspear, Michael; Colditz, Paul B.; de Vries, Linda S.; Benders, Manon J. N. L.; Klebermass-Schrehof, Katrin; Vanhatalo, Sampsa; Roberts, James A.
Other contributor: University of Helsinki, HUS Medical Imaging Center






Date: 2020-06
Language: eng
Number of pages: 12
Belongs to series: Annals of Clinical and Translational Neurology
ISSN: 2328-9503
DOI: https://doi.org/10.1002/acn3.51043
URI: http://hdl.handle.net/10138/318727
Abstract: Objective A major challenge in the care of preterm infants is the early identification of compromised neurological development. While several measures are routinely used to track anatomical growth, there is a striking lack of reliable and objective tools for tracking maturation of early brain function; a cornerstone of lifelong neurological health. We present a cot-side method for measuring the functional maturity of the newborn brain based on routinely available neurological monitoring with electroencephalography (EEG). Methods We used a dataset of 177 EEG recordings from 65 preterm infants to train a multivariable prediction of functional brain age (FBA) from EEG. The FBA was validated on an independent set of 99 EEG recordings from 42 preterm infants. The difference between FBA and postmenstrual age (PMA) was evaluated as a predictor for neurodevelopmental outcome. Results The FBA correlated strongly with the PMA of an infant, with a median prediction error of less than 1 week. Moreover, individual babies follow well-defined individual trajectories. The accuracy of the FBA applied to the validation set was statistically equivalent to the training set accuracy. In a subgroup of infants with repeated EEG recordings, a persistently negative predicted age difference was associated with poor neurodevelopmental outcome. Interpretation The FBA enables the tracking of functional neurodevelopment in preterm infants. This establishes proof of principle for growth charts for brain function, a new tool to assist clinical management and identify infants who will benefit most from early intervention.
Subject: POSTNATAL-GROWTH TRAJECTORIES
MATURATION
AMPLITUDE
EEG
MATURITY
HEALTH
TOOL
MRI
3112 Neurosciences
3124 Neurology and psychiatry
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