Changes in hemostasis parameters in nonfatal methicillin-sensitive Staphylococcus aureus bacteremia complicated by endocarditis or thromboembolic events : a prospective gender-age adjusted cohort study

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dc.contributor.author Forsblom, Erik
dc.contributor.author Lepäntalo, Aino
dc.contributor.author Wartiovaara-Kautto, Ulla
dc.contributor.author Ruotsalainen, Eeva
dc.contributor.author Järvinen, Asko
dc.date.accessioned 2020-08-31T01:54:54Z
dc.date.available 2021-12-18T03:45:31Z
dc.date.issued 2019-07
dc.identifier.citation Forsblom , E , Lepäntalo , A , Wartiovaara-Kautto , U , Ruotsalainen , E & Järvinen , A 2019 , ' Changes in hemostasis parameters in nonfatal methicillin-sensitive Staphylococcus aureus bacteremia complicated by endocarditis or thromboembolic events : a prospective gender-age adjusted cohort study ' , APMIS : Acta pathologica, microbiologica et immunologica Scandinavica , vol. 127 , no. 7 , pp. 515-528 . https://doi.org/10.1111/apm.12955
dc.identifier.other PURE: 126669444
dc.identifier.other PURE UUID: 119184d8-de8e-43ff-9c24-03bb73a41b54
dc.identifier.other WOS: 000473620900004
dc.identifier.uri http://hdl.handle.net/10138/318821
dc.description.abstract The aim of this study was to examine the changes in hemostasis parameters in endocarditis and thromboembolic events in nonfatal methicillin-sensitive Staphylococcus aureus bacteremia (MS-SAB) - a topic not evaluated previously. In total, 155 patients were recruited and were categorized according to the presence of endocarditis or thromboembolic events with gender-age adjusted controls. Patients who deceased within 90 days or patients not chosen as controls were excluded. SAB management was supervised by an infectious disease specialist. Patients with endocarditis (N = 21), compared to controls (N = 21), presented lower antithrombin III at day 4 (p <0.05), elevated antithrombin III at day 90 (p <0.01), prolonged activated partial thromboplastin time at days 4 and 10 (p <0.05), and enhanced thrombin-antithrombin complex at day 4 (p <0.01). Thromboembolic events (N = 8), compared to controls (N = 34), significantly increased thrombin-antithrombin complex at day 4 (p <0.05). In receiver operating characteristic analysis, the changes in these hemostasis parameters at day 4 predicted endocarditis and thromboembolic events (p <0.05). No differences in hemoglobin, thrombocyte, prothrombin fragment, thrombin time, factor VIII, D-dimer or fibrinogen levels were observed between cases and controls. The results suggest that nonfatal MS-SAB patients present marginal hemostasis parameter changes that, however, may have predictability for endocarditis or thromboembolic events. Larger studies are needed to further assess the connection of hemostasis to complications in SAB. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof APMIS : Acta pathologica, microbiologica et immunologica Scandinavica
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Endocarditis
dc.subject hemostasis
dc.subject infectious specialist consultation
dc.subject staphylococcus aureus bacteremia
dc.subject thromboembolic events
dc.subject INFECTIOUS-DISEASE CONSULTATION
dc.subject VENOUS THROMBOEMBOLISM
dc.subject PLATELET ACTIVATION
dc.subject BLOOD-COAGULATION
dc.subject INCREASED RISK
dc.subject D-DIMER
dc.subject MORTALITY
dc.subject PROTEIN
dc.subject ASSOCIATION
dc.subject MANAGEMENT
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3111 Biomedicine
dc.title Changes in hemostasis parameters in nonfatal methicillin-sensitive Staphylococcus aureus bacteremia complicated by endocarditis or thromboembolic events : a prospective gender-age adjusted cohort study en
dc.type Article
dc.contributor.organization HUS Inflammation Center
dc.contributor.organization Infektiosairauksien yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Hematologian yksikkö
dc.contributor.organization Department of Oncology
dc.contributor.organization University Management
dc.contributor.organization Department of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/apm.12955
dc.relation.issn 0903-4641
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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