Disparities in glioblastoma survival by case volume : a nationwide observational study

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http://hdl.handle.net/10138/318841

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Raj , R , Seppä , K , Luostarinen , T , Malila , N , Seppälä , M , Pitkäniemi , J & Korja , M 2020 , ' Disparities in glioblastoma survival by case volume : a nationwide observational study ' , Journal of Neuro-Oncology , vol. 147 , no. 2 , pp. 361-370 . https://doi.org/10.1007/s11060-020-03428-5

Title: Disparities in glioblastoma survival by case volume : a nationwide observational study
Author: Raj, Rahul; Seppä, Karri; Luostarinen, Tapio; Malila, Nea; Seppälä, Matti; Pitkäniemi, Janne; Korja, Miikka
Other contributor: University of Helsinki, HUS Neurocenter
University of Helsinki, HUS Neurocenter
University of Helsinki, Department of Public Health
University of Helsinki, HUS Neurocenter






Date: 2020-04
Language: eng
Number of pages: 10
Belongs to series: Journal of Neuro-Oncology
ISSN: 0167-594X
DOI: https://doi.org/10.1007/s11060-020-03428-5
URI: http://hdl.handle.net/10138/318841
Abstract: Introduction High hospital case volumes are associated with improved treatment outcomes for numerous diseases. We assessed the association between academic non-profit hospital case volume and survival of adult glioblastoma patients. Methods From the nationwide Finnish Cancer Registry, we identified all adult (>= 18 years) patients with histopathological diagnoses of glioblastoma from 2000 to 2013. Five university hospitals (treating all glioblastoma patients in Finland) were classified as high-volume (one hospital), middle-volume (one hospital), and low-volume (three hospitals) based on their annual numbers of cases. We estimated one-year survival rates, estimated median overall survival times, and compared relative excess risk (RER) of death between high, middle, and low-volume hospitals. Results A total of 2,045 patients were included. The mean numbers of annually treated patients were 54, 40, and 17 in the high, middle, and low-volume hospitals, respectively. One-year survival rates and median survival times were higher and longer in the high-volume (39%, 9.3 months) and medium-volume (38%, 8.9 months) hospitals than in the low-volume (32%, 7.8 months) hospitals. RER of death was higher in the low-volume hospitals than in the high-volume hospital (RER = 1.19, 95% CI 1.07-1.32, p = 0.002). There was no difference in RER of death between the high-volume and medium-volume hospitals (p = 0.690). Conclusion Higher glioblastoma case volumes were associated with improved survival. Future studies should assess whether this association is due to differences in patient-specific factors or treatment quality.
Subject: Glioblastoma
Glioma
Malignant glioma
Epidemiological study
Mortality
Outcome
HOSPITAL VOLUME
UNITED-STATES
TEMOZOLOMIDE
CANCER
CARE
3122 Cancers
3112 Neurosciences
3124 Neurology and psychiatry
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