Papillary Thyroid Cancer-Aggressive Variants and Impact on Management : A Narrative Review

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Coca-Pelaz , A , Shah , J P , Hernandez-Prera , J C , Ghossein , R A , Rodrigo , J P , Hartl , D M , Olsen , K D , Shaha , A R , Zafereo , M , Suarez , C , Nixon , I J , Randolph , G W , Mäkitie , A A , Kowalski , L P , Vander Poorten , V , Sanabria , A , Guntinas-Lichius , O , Simo , R , Zbaren , P , Angelos , P , Khafif , A , Rinaldo , A & Ferlito , A 2020 , ' Papillary Thyroid Cancer-Aggressive Variants and Impact on Management : A Narrative Review ' , Advances in Therapy , vol. 37 , no. 7 , pp. 3112-3128 . https://doi.org/10.1007/s12325-020-01391-1

Title: Papillary Thyroid Cancer-Aggressive Variants and Impact on Management : A Narrative Review
Author: Coca-Pelaz, Andres; Shah, Jatin P.; Hernandez-Prera, Juan C.; Ghossein, Ronald A.; Rodrigo, Juan P.; Hartl, Dana M.; Olsen, Kerry D.; Shaha, Ashok R.; Zafereo, Mark; Suarez, Carlos; Nixon, Iain J.; Randolph, Gregory W.; Mäkitie, Antti A.; Kowalski, Luiz P.; Vander Poorten, Vincent; Sanabria, Alvaro; Guntinas-Lichius, Orlando; Simo, Ricard; Zbaren, Peter; Angelos, Peter; Khafif, Avi; Rinaldo, Alessandra; Ferlito, Alfio
Contributor: University of Helsinki, HUS Head and Neck Center
Date: 2020-07
Language: eng
Number of pages: 17
Belongs to series: Advances in Therapy
ISSN: 0741-238X
URI: http://hdl.handle.net/10138/318866
Abstract: Introduction Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant. Methods We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients. Results At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor at presentation and the opinion of experienced clinicians. Conclusion These aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature.
Subject: Aggressive variants papillary thyroid cancer
Columnar cell variant
Diffuse sclerosis variant
Hobnail variant
Solid variant
Tall cell variant
DIFFUSE SCLEROSING VARIANT
COLUMNAR CELL VARIANT
NEEDLE-ASPIRATION-CYTOLOGY
TALL-CELL
HOBNAIL VARIANT
BRAF MUTATION
SOLID COMPONENT
CASE SERIES
CARCINOMA
FEATURES
3122 Cancers
317 Pharmacy
3125 Otorhinolaryngology, ophthalmology
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