Familial cancer risk in family members and spouses of patients with early-onset head and neck cancer

Show full item record



Permalink

http://hdl.handle.net/10138/318869

Citation

Mroueh , R , Tanskanen , T , Haapaniemi , A , Salo , T , Malila , N , Mäkitie , A & Pitkäniemi , J 2020 , ' Familial cancer risk in family members and spouses of patients with early-onset head and neck cancer ' , Head & Neck , vol. 42 , no. 9 , pp. 2524-2532 . https://doi.org/10.1002/hed.26282

Title: Familial cancer risk in family members and spouses of patients with early-onset head and neck cancer
Author: Mroueh, Rayan; Tanskanen, Tomas; Haapaniemi, Aaro; Salo, Tuula; Malila, Nea; Mäkitie, Antti; Pitkäniemi, Janne
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUSLAB
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Clinicum
Date: 2020-09
Language: eng
Number of pages: 9
Belongs to series: Head & Neck
ISSN: 1043-3074
URI: http://hdl.handle.net/10138/318869
Abstract: Background Reported patterns of familial aggregation of head and neck cancer (HNC) vary greatly, with many studies hampered by the limited number of subjects. Methods Altogether 923 early-onset ( Results Of all early-onset HNC families, only 21 (2.3%) had familial HNC cancers at any age and less than five familial early onset HNC cancers among first-degree relatives. The cumulative risk of HNC for siblings by age 60 (0.52%) was at population level (0.33%). No increased familial risk of early-onset HNC could be discerned in family members (SIR 2.68, 95% CI 0.32-9.68 for first-degree relatives). Conclusions Our study indicates that the cumulative and relative familial risk of early-onset HNC is modest in the Finnish population and, at most, only a minor proportion of early-onset HNCs are due solely to inherited genetic mutations.
Subject: early-onset cancer
familial cancer
head and neck cancer
proband
SQUAMOUS-CELL CARCINOMA
GENE-ENVIRONMENT INTERACTIONS
POOLED ANALYSIS
LUNG-CANCER
HUMAN-PAPILLOMAVIRUS
INTERNATIONAL HEAD
BREAST-CANCER
YOUNG-ADULTS
EPIDEMIOLOGY
POLYMORPHISMS
3125 Otorhinolaryngology, ophthalmology
3126 Surgery, anesthesiology, intensive care, radiology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
hed.26282.pdf 733.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record