Characteristics of Laryngeal Osteosarcoma : A Critical Review

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Mäkitie , A A , Devaney , K O , Baujat , B , Almangush , A & Ferlito , A 2020 , ' Characteristics of Laryngeal Osteosarcoma : A Critical Review ' , Oncology and therapy , vol. 8 , no. 1 , pp. 33-44 .

Title: Characteristics of Laryngeal Osteosarcoma : A Critical Review
Author: Mäkitie, Antti A.; Devaney, Kenneth O.; Baujat, Bertrand; Almangush, Alhadi; Ferlito, Alfio
Contributor organization: HUS Head and Neck Center
Department of Ophthalmology and Otorhinolaryngology
University of Helsinki
Research Program in Systems Oncology
Faculty of Medicine
Oral and Maxillofacial Surgery
Department of Pathology
Date: 2020-06
Language: eng
Number of pages: 12
Belongs to series: Oncology and therapy
ISSN: 2366-1070
Abstract: Laryngeal sarcomas constitute an extremely rare entity among head and neck malignancies. Furthermore, most of them are chondrosarcomas, and the osteogenic form remains a true rarity. In general, there is a lack of information on the characteristics of laryngeal osteosarcoma. Thus, we sought to critically review the existing world literature on laryngeal osteosarcoma in order to develop a more accurate clinicopathological profile of this malignancy. Laryngeal osteosarcoma has a predilection for elderly male patients, as 87% were male in the present series and the mean age was 62 years (range 32-80), and without a direct association with tobacco exposure. Osteosarcoma of the larynx is typically a highly malignant neoplasm that metastasizes early, has a propensity for hematogenous spread and also has a marked tendency to recur. Twelve (41%) out of the 29 cases in the present review with follow-up data had metastatic disease. The aspects that distinguish osteosarcoma from its differential diagnostic alternatives are discussed in this review.
Subject: Larynx
3122 Cancers
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion

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