Characteristics of Laryngeal Osteosarcoma : A Critical Review

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http://hdl.handle.net/10138/318879

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Mäkitie , A A , Devaney , K O , Baujat , B , Almangush , A & Ferlito , A 2020 , ' Characteristics of Laryngeal Osteosarcoma : A Critical Review ' , Oncology and therapy , vol. 8 , no. 1 , pp. 33-44 . https://doi.org/10.1007/s40487-020-00110-8

Titel: Characteristics of Laryngeal Osteosarcoma : A Critical Review
Författare: Mäkitie, Antti A.; Devaney, Kenneth O.; Baujat, Bertrand; Almangush, Alhadi; Ferlito, Alfio
Medarbetare: University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
Datum: 2020-06
Språk: eng
Sidantal: 12
Tillhör serie: Oncology and therapy
ISSN: 2366-1070
Permanenta länken (URI): http://hdl.handle.net/10138/318879
Abstrakt: Laryngeal sarcomas constitute an extremely rare entity among head and neck malignancies. Furthermore, most of them are chondrosarcomas, and the osteogenic form remains a true rarity. In general, there is a lack of information on the characteristics of laryngeal osteosarcoma. Thus, we sought to critically review the existing world literature on laryngeal osteosarcoma in order to develop a more accurate clinicopathological profile of this malignancy. Laryngeal osteosarcoma has a predilection for elderly male patients, as 87% were male in the present series and the mean age was 62 years (range 32-80), and without a direct association with tobacco exposure. Osteosarcoma of the larynx is typically a highly malignant neoplasm that metastasizes early, has a propensity for hematogenous spread and also has a marked tendency to recur. Twelve (41%) out of the 29 cases in the present review with follow-up data had metastatic disease. The aspects that distinguish osteosarcoma from its differential diagnostic alternatives are discussed in this review.
Subject: Larynx
Osteosarcoma
Radiotherapy
Sarcoma
Surgery
OSTEO-SARCOMA
SOFT-TISSUE
3122 Cancers
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