Antibiotics in early life associate with specific gut microbiota signatures in a prospective longitudinal infant cohort

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Korpela , K , Salonen , A , Saxen , H , Nikkonen , A , Peltola , V , Jaakkola , T , de Vos , W & Kolho , K-L 2020 , ' Antibiotics in early life associate with specific gut microbiota signatures in a prospective longitudinal infant cohort ' , Pediatric Research , vol. 88 , no. 3 , pp. 438–443 . https://doi.org/10.1038/s41390-020-0761-5

Title: Antibiotics in early life associate with specific gut microbiota signatures in a prospective longitudinal infant cohort
Author: Korpela, Katri; Salonen, Anne; Saxen, Harri; Nikkonen, Anne; Peltola, Ville; Jaakkola, Tytti; de Vos, Willem; Kolho, Kaija-Leena
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, HUMI - Human Microbiome Research
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Willem Meindert Vos de / Principal Investigator
University of Helsinki, Children's Hospital
Date: 2020-09
Language: eng
Number of pages: 6
Belongs to series: Pediatric Research
ISSN: 0031-3998
URI: http://hdl.handle.net/10138/318949
Abstract: BACKGROUND The effects of antibiotics on infant gut microbiota are unclear. We hypothesized that the use of common antibiotics results in long-term aberration in gut microbiota. METHODS Antibiotic-naive infants were prospectively recruited when hospitalized because of a respiratory syncytial virus infection. Composition of fecal microbiota was compared between those receiving antibiotics during follow-up (prescribed at clinicians' discretion because of complications such as otitis media) and those with no antibiotic exposure. Fecal sampling started on day 1, then continued at 2-day intervals during the hospital stay, and at 1, 3 and 6 months at home. RESULTS One hundred and sixty-three fecal samples from 40 patients (median age 2.3 months at baseline; 22 exposed to antibiotics) were available for microbiota analyses. A single course of amoxicillin or macrolide resulted in aberration of infant microbiota characterized by variation in the abundance of bifidobacteria, enterobacteria and clostridia, lasting for several months. Recovery from the antibiotics was associated with an increase in clostridia. Occasionally, antibiotic use resulted in microbiota profiles associated with inflammatory conditions. CONCLUSIONS Antibiotic use in infants modifies especially bifidobacterial levels. Further studies are warranted whether administration of bifidobacteria will provide health benefits by normalizing the microbiota in infants receiving antibiotics.
Subject: INTESTINAL MICROBIOTA
COLONIZATION
CHILDREN
DISEASE
CROHNS
SUSCEPTIBILITY
BACTERIAL
EXPOSURE
RECOVERY
REVEALS
3123 Gynaecology and paediatrics
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