Association of anthropometry and weight change with risk of dementia and its major subtypes : A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia

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Lee , C M , Woodward , M , Batty , G D , Beiser , A S , Bell , S , Berr , C , Bjertness , E , Chalmers , J , Clarke , R , Dartigues , J-F , Davis-Plourde , K , Debette , S , Di Angelantonio , E , Feart , C , Frikke-Schmidt , R , Gregson , J , Haan , M N , Hassing , L B , Hayden , K M , Hoevenaar-Blom , M P , Kaprio , J , Kivimäki , M , Lappas , G , Larson , E B , LeBlanc , E S , Lee , A , Lui , L-Y , van Charante , E P M , Ninomiya , T , Nordestgaard , L T , Ohara , T , Ohkuma , T , Palviainen , T , Peres , K , Peters , R , Qizilbash , N , Richard , E , Rosengren , A , Seshadri , S , Shipley , M , Singh-Manoux , A , Strand , B H , van Gool , W A , Vuoksimaa , E , Yaffe , K & Huxley , R R 2020 , ' Association of anthropometry and weight change with risk of dementia and its major subtypes : A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia ' , Obesity Reviews , vol. 21 , no. 4 , e12989 . https://doi.org/10.1111/obr.12989

Title: Association of anthropometry and weight change with risk of dementia and its major subtypes : A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia
Author: Lee, Crystal ManYing; Woodward, Mark; Batty, G. David; Beiser, Alexa S.; Bell, Steven; Berr, Claudine; Bjertness, Espen; Chalmers, John; Clarke, Robert; Dartigues, Jean-Francois; Davis-Plourde, Kendra; Debette, Stephanie; Di Angelantonio, Emanuele; Feart, Catherine; Frikke-Schmidt, Ruth; Gregson, John; Haan, Mary N.; Hassing, Linda B.; Hayden, Kathleen M.; Hoevenaar-Blom, Marieke P.; Kaprio, Jaakko; Kivimäki, Mika; Lappas, Georgios; Larson, Eric B.; LeBlanc, Erin S.; Lee, Anne; Lui, Li-Yung; van Charante, Eric P. Moll; Ninomiya, Toshiharu; Nordestgaard, Liv Tybjaerg; Ohara, Tomoyuki; Ohkuma, Toshiaki; Palviainen, Teemu; Peres, Karine; Peters, Ruth; Qizilbash, Nawab; Richard, Edo; Rosengren, Annika; Seshadri, Sudha; Shipley, Martin; Singh-Manoux, Archana; Strand, Bjorn Heine; van Gool, Willem A.; Vuoksimaa, Eero; Yaffe, Kristine; Huxley, Rachel R.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Public Health
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Cognitive and Brain Aging
Date: 2020-04
Language: eng
Number of pages: 14
Belongs to series: Obesity Reviews
ISSN: 1467-7881
URI: http://hdl.handle.net/10138/318955
Abstract: Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index-defined lower-normal weight (18.5-22.4 kg/m(2)), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5-24.9 kg/m(2)) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non-linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.
Subject: BODY-MASS INDEX
FOLLOW-UP
ALZHEIMERS-DISEASE
VASCULAR DEMENTIA
FUTURE RISK
LATE-LIFE
MIDLIFE
MORTALITY
OBESITY
POPULATION
3121 Internal medicine
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