Maternal pre-pregnancy overweight and gestational diabetes and dietary intakes among young adult offspring

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Kaseva , N , Vääräsmaki , M , Matinolli , H-M , Sipola , M , Tikanmäki , M , Kanerva , N , Heinonen , K , Lano , A , Wolke , D , Andersson , S , Jarvelin , M-R , Räikkönen , K , Eriksson , J G , Männistö , S & Kajantie , E 2020 , ' Maternal pre-pregnancy overweight and gestational diabetes and dietary intakes among young adult offspring ' , Nutrition & Diabetes , vol. 10 , no. 1 , 26 . https://doi.org/10.1038/s41387-020-00129-w

Title: Maternal pre-pregnancy overweight and gestational diabetes and dietary intakes among young adult offspring
Author: Kaseva, Nina; Vääräsmaki, Marja; Matinolli, Hanna-Maria; Sipola, Marika; Tikanmäki, Marjaana; Kanerva, Noora; Heinonen, Kati; Lano, Aulikki; Wolke, Dieter; Andersson, Sture; Jarvelin, Marjo-Riitta; Räikkönen, Katri; Eriksson, Johan G.; Männistö, Satu; Kajantie, Eero
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Doctoral Programme in Psychology, Learning and Communication
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, University of Warwick
University of Helsinki, Clinicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Clinicum
University of Helsinki, HUS Children and Adolescents













Date: 2020-07-23
Language: eng
Number of pages: 12
Belongs to series: Nutrition & Diabetes
ISSN: 2044-4052
DOI: https://doi.org/10.1038/s41387-020-00129-w
URI: http://hdl.handle.net/10138/319049
Abstract: Background/Objectives Maternal pre-pregnancy overweight/obesity and gestational diabetes (GDM) are associated with increased fat deposition in adult offspring. The purpose of this study was to identify if maternal pre-pregnancy overweight (body mass index (BMI) >= 25 kg/m(2)) or GDM are associated with dietary quality or intake in adult offspring. Subjects/Methods Participants (n = 882) from two longitudinal cohort studies (ESTER Maternal Pregnancy Disorders Study and the Arvo Ylppo Longitudinal Study) completed a validated food-frequency questionnaire at a mean age of 24.2 years (SD 1.3). Diet quality was evaluated by a Recommended Finnish Diet Index (RDI). The study sample included offspring of normoglycaemic mothers with pre-pregnancy overweight/obesity (ONO = 155), offspring of mothers with GDM regardless of BMI (OGDM = 190) and offspring of mothers with normal weight and no GDM (controls;n = 537). Results Among men, daily energy and macronutrient intakes were similar in ONO and controls. However, after adjusting for current offspring characteristics, including BMI, daily carbohydrate intake relative to total energy intake was higher in ONO-men [2.2 percentages of total energy intake (95% confidence interval 0.4, 4.0)]. In ONO-women, macronutrient intakes relative to total energy intake were similar with controls, while total daily energy intake seemed lower [-587.2 kJ/day (-1192.0, 4.4)]. After adjusting for confounders, this difference was attenuated. Adherence to a healthy diet, as measured by RDI, was similar in ONO and controls [mean difference: men 0.40 (-0.38, 1.18); women 0.25 (-0.50, 1.00)]. In OGDM vs. controls, total energy and macronutrient intakes were similar for both men and women. Also adherence to a healthy diet was similar [RDI: men 0.09 (-0.62, 0.80); women -0.17 (-0.93, 0.59)]. Conclusions Our study suggested higher daily carbohydrate intake in male offspring exposed to maternal pre-pregnancy overweight/obesity, compared with controls. Prenatal exposure to GDM was not associated with adult offspring dietary intakes.
Subject: FOOD FREQUENCY QUESTIONNAIRE
ENERGY-INTAKE
BIRTH-WEIGHT
MISSING HERITABILITY
AGE
BORN
VALIDITY
BMI
RECOMMENDATIONS
ASSOCIATION
3121 General medicine, internal medicine and other clinical medicine
3143 Nutrition
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