Type 1 and type 2 diabetes after gestational diabetes : a 23 year cohort study

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Auvinen , A-M , Luiro , K , Jokelainen , J , Järvelä , I , Knip , M , Auvinen , J & Tapanainen , J S 2020 , ' Type 1 and type 2 diabetes after gestational diabetes : a 23 year cohort study ' , Diabetologia , vol. 63 , no. 10 , pp. 2123-2128 . https://doi.org/10.1007/s00125-020-05215-3

Title: Type 1 and type 2 diabetes after gestational diabetes : a 23 year cohort study
Author: Auvinen, Anna-Maaria; Luiro, Kaisu; Jokelainen, Jari; Järvelä, Ilkka; Knip, Mikael; Auvinen, Juha; Tapanainen, Juha S.
Contributor organization: Clinicum
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
University of Helsinki
Helsinki University Hospital Area
HUS Children and Adolescents
Children's Hospital
Research Programs Unit
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
Reproductive Disease Modeling
Date: 2020-10
Language: eng
Number of pages: 6
Belongs to series: Diabetologia
ISSN: 0012-186X
DOI: https://doi.org/10.1007/s00125-020-05215-3
URI: http://hdl.handle.net/10138/319146
Abstract: Aims/hypothesis The aim of this work was to examine the progression to type 1 and type 2 diabetes after gestational diabetes mellitus (GDM) in a 23 year follow-up study. Methods We carried out a cohort study of 391 women with GDM diagnosed by an OGTT or the use of insulin treatment during pregnancy, and 391 age- and parity-matched control participants, who delivered in 1984-1994 at the Oulu University Hospital, Finland. Diagnostic cut-off levels for glucose were as follows: fasting, >= 4.8 mmol/l; 1 h, >= 10.0 mmol/l; and 2 h, >= 8.7 mmol/l. Two follow-up questionnaires were sent (in 1995-1996 and 2012-2013) to assess the progression to type 1 and type 2 diabetes. Mean follow-up time was 23.1 (range 18.7-28.8) years. Results Type 1 diabetes developed (5.7%) during the first 7 years after GDM pregnancy and was predictable at a 2 h OGTT value of 11.9 mmol/l during pregnancy (receiver operating characteristic analysis: AUC 0.91, sensitivity 76.5%, specificity 96.0%). Type 2 diabetes increased linearly to 50.4% by the end of the follow-up period and was moderately predictable with fasting glucose (AUC 0.69, sensitivity 63.5%, specificity 68.2%) at a level of 5.1 mmol/l (identical to the fasting glucose cut-off recommended by the International Association of Diabetes and Pregnancy Study Groups [IADPSG) and WHO]). Conclusions/interpretation All women with GDM should be intensively monitored for a decade, after which the risk for type 1 diabetes is minimal. However, the incidence of type 2 diabetes remains linear, and therefore individualised lifelong follow-up is recommended.
Subject: GDM
Type 1 diabetes
Type 2 diabetes
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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