Staging and grading of oral squamous cell carcinoma : An update

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http://hdl.handle.net/10138/319148

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Almangush , A , Mäkitie , A A , Triantafyllou , A , de Bree , R , Strojan , P , Rinaldo , A , Hernandez-Prera , J C , Suarez , C , Kowalski , L P , Ferlito , A & Leivo , I 2020 , ' Staging and grading of oral squamous cell carcinoma : An update ' , Oral Oncology , vol. 107 , 104799 . https://doi.org/10.1016/j.oraloncology.2020.104799

Title: Staging and grading of oral squamous cell carcinoma : An update
Author: Almangush, Alhadi; Mäkitie, Antti A.; Triantafyllou, Asterios; de Bree, Remco; Strojan, Primoz; Rinaldo, Alessandra; Hernandez-Prera, Juan C.; Suarez, Carlos; Kowalski, Luiz P.; Ferlito, Alfio; Leivo, Ilmo
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
Date: 2020-08
Language: eng
Number of pages: 6
Belongs to series: Oral Oncology
ISSN: 1368-8375
URI: http://hdl.handle.net/10138/319148
Abstract: Oral squamous cell carcinoma (OSCC) is a common malignancy of the head and neck region. OSCC has a relatively low survival rate and the incidence of the disease is increasing in some geographic areas. Staging and grading of OSCC are established prerequisites for management, as they influence risk stratification and are the first step toward personalized treatment. The current AJCC/UICC TNM staging (8th edition, 2017) of OSCC has included significant modifications through the incorporation of depth of invasion in the T stage and extracapsular spread/extranodal extension in the N stage. Further modifications for AJCC 8 have been suggested. On the other hand, the World Health Organization (WHO) classification (4th edition, 2017) still endorses a simple, differentiation-based histopathologic grading system of OSCC (despite its low prognostic value) and ignores factors such as tumor growth pattern and dissociation, stromal reactions (desmoplasia, local immune response), and tumor-stroma ratio. The various controversies and possible developments of the current staging and grading criteria of OSCC are briefly discussed in this update together with possible applications of artificial intelligence in the context of screening and risk stratification.
Subject: Oral squamous cell carcinoma (OSCC)
Staging
Grading
Prognosis
AMERICAN JOINT COMMITTEE
8TH EDITION
TUMOR THICKNESS
NECK CANCERS
MALIGNANCY
CAVITY
CLASSIFICATION
PREDICTION
INDICATOR
SURVIVAL
3122 Cancers
313 Dentistry
3126 Surgery, anesthesiology, intensive care, radiology
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