Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood : A Multicenter Study

Show simple item record Haavisto, Anu Mathiesen, Sidsel Suominen, Anu Lähteenmäki, Päivi Sorensen, Kaspar Ifversen, Marianne Juul, Anders Nielsen, Malene Mejdahl Müller, Klaus Jahnukainen, Kirsi 2020-09-09T07:15:01Z 2020-09-09T07:15:01Z 2020-07
dc.identifier.citation Haavisto , A , Mathiesen , S , Suominen , A , Lähteenmäki , P , Sorensen , K , Ifversen , M , Juul , A , Nielsen , M M , Müller , K & Jahnukainen , K 2020 , ' Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood : A Multicenter Study ' , Cancers , vol. 12 , no. 7 , 1786 .
dc.identifier.other PURE: 144162949
dc.identifier.other PURE UUID: 35bb457e-c3a4-43d7-980e-de8fb435f482
dc.identifier.other WOS: 000554796700001
dc.identifier.other ORCID: /0000-0001-7670-4766/work/85521212
dc.description.abstract There are many known endocrine complications after allogeneic hematopoietic stem cell transplantation (HSCT) in childhood including increased risk of biochemical hypogonadism. However, little is known about sexuality in adulthood following childhood HSCT. In this multicenter study, sexual functions and possible risk factors were assessed comprehensively in two national cohorts (Finland and Denmark) of male adult survivors of childhood HSCT. Compared to a healthy control group (n= 56), HSCT survivors (n= 97) reported less sexual fantasies, poorer orgasms, lower sexual activity with a partner and reduced satisfaction with their sex life, even in the presence of normal erectile functions and a similar frequency of autoerotic acts. Of the HSCT survivors, 35% were cohabitating/married and 66% were sexually active. Risk factors for poorer self-reported sexual functions were partner status (not cohabitating with a partner), depressive symptoms, CNS and testicular irradiation. Sexual dysfunction increased by age in the HSCT group with a pace comparable to that of the control group. However, because of the lower baseline level of sexual functions in the HSCT group, they will reach the level of clinically significant dysfunction at a younger age. Hence, male survivors of childhood HSCT should be interviewed in detail about their sexual health beyond erectile functions. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof Cancers
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject HSCT
dc.subject children
dc.subject long-term survivors
dc.subject pediatric cancer
dc.subject sexual dysfunction
dc.subject late effects
dc.subject QUALITY-OF-LIFE
dc.subject OUTCOMES
dc.subject DYSFUNCTION
dc.subject DEPRESSION
dc.subject MALIGNANCY
dc.subject PROJECT
dc.subject 3123 Gynaecology and paediatrics
dc.subject 3122 Cancers
dc.subject 515 Psychology
dc.title Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood : A Multicenter Study en
dc.type Article
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization University of Helsinki
dc.contributor.organization Children's Hospital
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization Clinicum
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2072-6694
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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