The LifeCycle Project-EU Child Cohort Network : a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

Show full item record



Permalink

http://hdl.handle.net/10138/319187

Citation

LifeCycle Project Grp , Jaddoe , V W V , Felix , J F , Andersen , A-M N , Eriksson , J G & Duijts , L 2020 , ' The LifeCycle Project-EU Child Cohort Network : a federated analysis infrastructure and harmonized data of more than 250,000 children and parents ' , European Journal of Epidemiology , vol. 35 , no. 7 , pp. 709-724 . https://doi.org/10.1007/s10654-020-00662-z

Title: The LifeCycle Project-EU Child Cohort Network : a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
Author: LifeCycle Project Grp; Jaddoe, Vincent W. V.; Felix, Janine F.; Andersen, Anne-Marie Nybo; Eriksson, Johan G.; Duijts, Liesbeth
Contributor organization: Clinicum
Research Programs Unit
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
University of Helsinki
Helsinki University Hospital Area
Date: 2020-07
Language: eng
Number of pages: 16
Belongs to series: European Journal of Epidemiology
ISSN: 0393-2990
DOI: https://doi.org/10.1007/s10654-020-00662-z
URI: http://hdl.handle.net/10138/319187
Abstract: Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.
Subject: Consortium
Birth cohorts
Exposome
Life course
Non-communicable diseases
FOLIC-ACID SUPPLEMENTS
DNA METHYLATION
BLOOD-PRESSURE
BIRTH-WEIGHT
EARLY NUTRITION
GENERATION R
RISK-FACTORS
PREGNANCY
PROFILE
ASSOCIATION
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
Jaddoe2020_Arti ... ycleProject_EUChildCoh.pdf 1.215Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record