Genome wide association study of 40 clinical measurements in eight dog breeds

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Momozawa , Y , Merveille , A-C , Battaille , G , Wiberg , M , Koch , J , Willesen , J L , Proschowsky , H F , Gouni , V , Chetboul , V , Tiret , L , Fredholm , M , Seppälä , E H , Lohi , H , Georges , M & Lequarre , A-S 2020 , ' Genome wide association study of 40 clinical measurements in eight dog breeds ' , Scientific Reports , vol. 10 , no. 1 , 6520 . https://doi.org/10.1038/s41598-020-63457-y

Title: Genome wide association study of 40 clinical measurements in eight dog breeds
Author: Momozawa, Yukihide; Merveille, Anne-Christine; Battaille, Geraldine; Wiberg, Maria; Koch, Jørgen; Willesen, Jakob Lundgren; Proschowsky, Helle Friis; Gouni, Vassiliki; Chetboul, Valerie; Tiret, Laurent; Fredholm, Merete; Seppälä, Eija H.; Lohi, Hannes; Georges, Michel; Lequarre, Anne-Sophie
Contributor: University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Department of Medical and Clinical Genetics
University of Helsinki, Helsinki One Health (HOH)
Date: 2020-04-16
Language: eng
Number of pages: 11
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/319273
Abstract: The domestic dog represents an ideal model for identifying susceptibility genes, many of which are shared with humans. In this study, we investigated the genetic contribution to individual differences in 40 clinically important measurements by a genome-wide association study (GWAS) in a multinational cohort of 472 healthy dogs from eight breeds. Meta-analysis using the binary effects model after breed-specific GWAS, identified 13 genome-wide significant associations, three of them showed experimental-wide significant associations. We detected a signal at chromosome 13 for the serum concentration of alanine aminotransferase (ALT) in which we detected four breed-specific signals. A large proportion of the variance of ALT (18.1-47.7%) was explained by this locus. Similarly, a single SNP was also responsible for a large proportion of the variance (6.8-78.4%) for other measurements such as fructosamine, stress during physical exam, glucose, and morphometric measurements. The genetic contribution of single variant was much larger than in humans. These findings illustrate the importance of performing meta-analysis after breed-specific GWAS to reveal the genetic contribution to individual differences in clinically important measurements, which would lead to improvement of veterinary medicine.
Subject: GOLDEN RETRIEVER DOGS
ARCHITECTURE
DISEASE
COMPLEX
LOCI
SIZE
413 Veterinary science
1184 Genetics, developmental biology, physiology
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