Prenatal exposure to antiepileptic drugs and early processing of emotionally relevant sounds

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Videman , M , Stjerna , S , Wikstrom , V , Nybo , T , Roivainen , R , Vanhatalo , S , Huotilainen , M & Gaily , E 2019 , ' Prenatal exposure to antiepileptic drugs and early processing of emotionally relevant sounds ' , Epilepsy & Behavior , vol. 100 , 106503 . https://doi.org/10.1016/j.yebeh.2019.106503

Title: Prenatal exposure to antiepileptic drugs and early processing of emotionally relevant sounds
Author: Videman, Mari; Stjerna, Susanna; Wikstrom, Valtteri; Nybo, Taina; Roivainen, Reina; Vanhatalo, Sampsa; Huotilainen, Minna; Gaily, Eija
Contributor organization: HUS Children and Adolescents
Children's Hospital
HUS Neurocenter
Kliinisen neurofysiologian yksikkö
Department of Psychology and Logopedics
Cognitive Brain Research Unit
Neurologian yksikkö
Department of Neurosciences
HUS Medical Imaging Center
University of Helsinki
Department of Education
Behavioural Sciences
CICERO Learning
Lastenneurologian yksikkö
AGORA for the study of social justice and equality in education -research centre
Brain, Music and Learning
Mind and Matter
Date: 2019-11
Language: eng
Number of pages: 8
Belongs to series: Epilepsy & Behavior
ISSN: 1525-5050
DOI: https://doi.org/10.1016/j.yebeh.2019.106503
URI: http://hdl.handle.net/10138/319306
Abstract: Introduction: Prenatal exposure to antiepileptic drugs (AEDs) is associated with developmental compromises in verbal intelligence and social skills in childhood. Our aim was to evaluate whether a multifeature Mismatch Negativity (MMN) paradigm assessing semantic and emotional components of linguistic and emotional processing would be useful to detect possible alterations in early auditory processing of newborns with prenatal AED exposure. Material and methods: Data on AED exposure. pregnancy outcome, neuropsychological evaluation of the mothers, information on maternal epilepsy type, and a structured neurological examination of the newborn were collected prospectively. Blinded to AED exposure, we compared a cohort of 36 AED-exposed with 46 control newborns at the age of two weeks by measuring MMN with a multifeature paradigm with six linguistically relevant deviant sounds and three emotionally uttered sounds. Results: Frontal responses for the emotionally uttered stimulus Happy differed significantly in the exposed newborns compared with the control newborns. In addition, responses to sounds with or without emotional component differed in newborns exposed to multiple AEDs compared with control newborns or to newborns exposed to only one AED. Conclusions: These preliminary findings suggest that prenatal AED exposure may alter early processing of emotionally and linguistically relevant sound information. (C) 2019 Elsevier Inc. All rights reserved.
Subject: Evoked potentials
Epilepsy
Newborn
Fetal
Pregnancy
Intrauterine
EVENT-RELATED POTENTIALS
MISMATCH NEGATIVITY MMN
VALPROATE EXPOSURE
COGNITIVE OUTCOMES
EVOKED-POTENTIALS
SPECTRUM DISORDER
TERM INFANTS
CHILDREN
DISCRIMINATION
LANGUAGE
515 Psychology
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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