Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

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dc.contributor University of Helsinki, HUS Heart and Lung Center en
dc.contributor.author Roumans, Kay H. M.
dc.contributor.author Lindeboom, Lucas
dc.contributor.author Veeraiah, Pandichelvam
dc.contributor.author Remie, Carlijn M. E.
dc.contributor.author Phielix, Esther
dc.contributor.author Havekes, Bas
dc.contributor.author Bruls, Yvonne M. H.
dc.contributor.author Brouwers, Martijn C. G. J.
dc.contributor.author Stahlman, Marcus
dc.contributor.author Alssema, Marjan
dc.contributor.author Peters, Harry P. F.
dc.contributor.author de Mutsert, Renee
dc.contributor.author Staels, Bart
dc.contributor.author Taskinen, Marja-Riitta
dc.contributor.author Boren, Jan
dc.contributor.author Schrauwen, Patrick
dc.contributor.author Schrauwen-Hinderling, Vera B.
dc.date.accessioned 2020-09-14T09:55:01Z
dc.date.available 2020-09-14T09:55:01Z
dc.date.issued 2020-04-20
dc.identifier.citation Roumans , K H M , Lindeboom , L , Veeraiah , P , Remie , C M E , Phielix , E , Havekes , B , Bruls , Y M H , Brouwers , M C G J , Stahlman , M , Alssema , M , Peters , H P F , de Mutsert , R , Staels , B , Taskinen , M-R , Boren , J , Schrauwen , P & Schrauwen-Hinderling , V B 2020 , ' Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance ' , Nature Communications , vol. 11 , no. 1 , 1891 . https://doi.org/10.1038/s41467-020-15684-0 en
dc.identifier.issn 2041-1723
dc.identifier.other PURE: 144438484
dc.identifier.other PURE UUID: f006df58-66a7-4e0d-a670-dc6e6ceb3b1c
dc.identifier.other WOS: 000558827500026
dc.identifier.other ORCID: /0000-0002-6229-3588/work/90756924
dc.identifier.uri http://hdl.handle.net/10138/319324
dc.description.abstract Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (H-1-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our H-1-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity. Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use H-1-MRS methodology to show hepatic SFA fraction is a measure of DNL and specifically may hamper hepatic insulin sensitivity. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights en
dc.subject LIVER-DISEASE en
dc.subject CARDIOVASCULAR-DISEASE en
dc.subject RISK en
dc.subject SPECTROSCOPY en
dc.subject STEATOSIS en
dc.subject BRAIN en
dc.subject MICE en
dc.subject 3121 General medicine, internal medicine and other clinical medicine en
dc.title Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1038/s41467-020-15684-0
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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