Resection margins and local recurrences of impalpable breast cancer : Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL)

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Niinikoski , L , Hukkinen , K , Leidenius , M H K , Vaara , P , Voynov , A , Heikkila , P , Mattson , J & Meretoja , T J 2019 , ' Resection margins and local recurrences of impalpable breast cancer : Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL) ' , Breast , vol. 47 , pp. 93-101 . https://doi.org/10.1016/j.breast.2019.07.004

Title: Resection margins and local recurrences of impalpable breast cancer : Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL)
Author: Niinikoski, Laura; Hukkinen, Katja; Leidenius, Marjut H. K.; Vaara, Paivi; Voynov, Aleksandar; Heikkila, Paivi; Mattson, Johanna; Meretoja, Tuomo J.
Contributor: University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, Department of Oncology
University of Helsinki, HUSLAB
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, HUS Comprehensive Cancer Center
Date: 2019-10
Number of pages: 9
Belongs to series: Breast
ISSN: 0960-9776
URI: http://hdl.handle.net/10138/319380
Abstract: Objectives: The aim of this retrospective study is to compare surgical margins, reoperation rates and local recurrences after breast conserving surgery (BCS) using radioguided occult lesion localization (ROLL) or radioactive seed localization (RSL). Materials and methods: We reviewed 744 consecutive patients with impalpable primary invasive breast cancer who underwent BCS at Helsinki University Hospital between 2010 and 2012. ROLL was used in our unit until October 31st, 2011; from November 1st we changed localization method to RSL. Results: 318 patients underwent ROLL and 426 RSL. Patients in the RSL group had more often multifocal (p = 0.013) tumours. No statistically significant differences were found regarding tumour size, specimen weight, histology or grade of tumours or lymph node status. 42 (5.6%) patients were reoperated because of insufficient margins, 13 (4.1%) in the ROLL group and 29 (6.8%) in the RSL group. The reoperation rate was not different between the groups either in the univariable analysis (p = 0.112) or in the multivariable binary logistic regression analysis (p = 0.204). Risk factors for reoperations were multifocality of the tumour (p Conclusion: Reoperation rates and LRFS were comparable for ROLL and RSL in patients with impalpable breast cancer treated with BCS. (C) 2019 Elsevier Ltd. All rights reserved.
Subject: Breast cancer
Breast conserving surgery
Radioguided occult lesion localization
Radioactive seed localization
Surgical margins
Local recurrence
WIRE-GUIDED LOCALIZATION
CONSERVING SURGERY
NODES
3122 Cancers
3123 Gynaecology and paediatrics
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