High TKTL1 expression as a sign of poor prognosis in colorectal cancer with synchronous rather than metachronous liver metastases : Cancer Biology & Therapy

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dc.contributor University of Helsinki, HUS Abdominal Center en
dc.contributor University of Helsinki, Department of Surgery en
dc.contributor University of Helsinki, HUS Head and Neck Center en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, HUS Abdominal Center en
dc.contributor University of Helsinki, HUS Abdominal Center en
dc.contributor.author Peltonen, Reetta
dc.contributor.author Ahopelto, Kaisa
dc.contributor.author Hagström, Jaana
dc.contributor.author Böckelman, Camilla
dc.contributor.author Haglund, Caj
dc.contributor.author Isoniemi, Helena
dc.date.accessioned 2020-09-16T06:29:01Z
dc.date.available 2020-09-16T06:29:01Z
dc.date.issued 2020-08-16
dc.identifier.citation Peltonen , R , Ahopelto , K , Hagström , J , Böckelman , C , Haglund , C & Isoniemi , H 2020 , ' High TKTL1 expression as a sign of poor prognosis in colorectal cancer with synchronous rather than metachronous liver metastases : Cancer Biology & Therapy ' , Cancer Biology & Therapy , pp. 826-831 . https://doi.org/10.1080/15384047.2020.1803008 en
dc.identifier.issn 1538-4047
dc.identifier.other PURE: 143038300
dc.identifier.other PURE UUID: eac152b3-5038-4a70-b363-cc7ccc5bdf8d
dc.identifier.other RIS: urn:92C4FA8D8C3B862F20AE09BFFCB9FA6E
dc.identifier.other WOS: 000560606900001
dc.identifier.other ORCID: /0000-0001-6079-7881/work/80576037
dc.identifier.uri http://hdl.handle.net/10138/319385
dc.description.abstract ABSTRACT Colorectal cancer (CRC) is the third most common cancer in the world. More than half of all affected patients develop liver metastases during the course of the disease, and over half experience recurrence despite radical primary surgery. Transketolase-like protein 1 (TKTL1) is a key enzyme in the glucose metabolism of cancer cells, and its expression in tumor tissue was previously shown to indicate a poor prognosis in colorectal cancer. In this study, we investigated the prognostic significance of TKTL1 in 111 patients with surgically resected colorectal liver metastases, with a minimum follow-up time of 10.3 years. TKTL1 expression was examined in tissue samples of both primary tumors and liver metastases, and compared to clinicopathological parameters, disease-free survival, and overall survival. We show that a high expression of TKTL1 in primary tumor tissue associated with poor disease-free survival in patients with synchronous liver metastases (P = .026, Kaplan-Meier log-rank test), but with better disease-free survival in patients with metachronous metastases, although not statistically significantly (P = .073). We found similar tendencies for TKTL1 expression in liver metastases. Thus, TKTL1 could serve as a candidate marker to identify patients who benefit from liver resection or who need more aggressive perioperative chemotherapy. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Cancer Biology & Therapy
dc.rights en
dc.subject 3122 Cancers en
dc.subject TKTL1 en
dc.subject colorectal cancer en
dc.subject liver metastases en
dc.subject liver resection en
dc.subject prognosis en
dc.subject immunohistochemistry en
dc.subject tumor markers en
dc.title High TKTL1 expression as a sign of poor prognosis in colorectal cancer with synchronous rather than metachronous liver metastases : Cancer Biology & Therapy en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1080/15384047.2020.1803008
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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