Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

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Jelenkovic , A , Sund , R , Yokoyama , Y , Latvala , A , Sugawara , M , Tanaka , M , Matsumoto , S , Freitas , D L , Maia , J A , Knafo-Noam , A , Mankuta , D , Abramson , L , Ji , F , Ning , F , Pang , Z , Rebato , E , Saudino , K J , Cutler , T L , Hopper , J L , Ullemar , V , Almqvist , C , Magnusson , P K E , Cozen , W , Hwang , A E , Mack , T M , Nelson , T L , Whitfield , K E , Sung , J , Kim , J , Lee , J , Lee , S , Llewellyn , C H , Fisher , A , Medda , E , Nistico , L , Toccaceli , V , Baker , L A , Tuvblad , C , Corley , R P , Huibregtse , B M , Derom , C A , Vlietinck , R F , Loos , R J F , Burt , S A , Klump , K L , Silberg , J L , Maes , H H , Krueger , R F , McGue , M , Pahlen , S , Gatz , M , Butler , D A , Harris , J R , Brandt , I , Nilsen , T S , Harden , K P , Tucker-Drob , E M , Franz , C E , Kremen , W S , Lyons , M J , Lichtenstein , P , Bartels , M , van Beijsterveldt , C E M , Willemsen , G , Oncel , S Y , Aliev , F , Jeong , H-U , Hur , Y-M , Turkheimer , E , Boomsma , D , Srensen , T I A , Kaprio , J & Silventoinen , K 2020 , ' Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education ' , Scientific Reports , vol. 10 , no. 1 , 7974 . https://doi.org/10.1038/s41598-020-64883-8

Title: Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education
Author: Jelenkovic, Aline; Sund, Reijo; Yokoyama, Yoshie; Latvala, Antti; Sugawara, Masumi; Tanaka, Mami; Matsumoto, Satoko; Freitas, Duarte L.; Maia, Jose Antonio; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Saudino, Kimberly J.; Cutler, Tessa L.; Hopper, John L.; Ullemar, Vilhelmina; Almqvist, Catarina; Magnusson, Patrik K. E.; Cozen, Wendy; Hwang, Amie E.; Mack, Thomas M.; Nelson, Tracy L.; Whitfield, Keith E.; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Llewellyn, Clare H.; Fisher, Abigail; Medda, Emanuela; Nistico, Lorenza; Toccaceli, Virgilia; Baker, Laura A.; Tuvblad, Catherine; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Burt, S. Alexandra; Klump, Kelly L.; Silberg, Judy L.; Maes, Hermine H.; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Gatz, Margaret; Butler, David A.; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas S.; Harden, K. Paige; Tucker-Drob, Elliot M.; Franz, Carol E.; Kremen, William S.; Lyons, Michael J.; Lichtenstein, Paul; Bartels, Meike; van Beijsterveldt, Catharina E. M.; Willemsen, Gonneke; Oncel, Sevgi Y.; Aliev, Fazil; Jeong, Hoe-Uk; Hur, Yoon-Mi; Turkheimer, Eric; Boomsma, Dorret; Srensen, Thorkild I. A.; Kaprio, Jaakko; Silventoinen, Karri
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Social Research (2010-2017)
University of Helsinki, Institute of Criminology and Legal Policy
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Helsinki Inequality Initiative (INEQ)









Date: 2020-05-14
Language: eng
Number of pages: 11
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-020-64883-8
URI: http://hdl.handle.net/10138/319440
Abstract: Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.
Subject: GENOME-WIDE ASSOCIATION
MATERNAL EDUCATION
TWINS
GROWTH
HERITABILITY
CHILDREN
PROJECT
LOCI
3142 Public health care science, environmental and occupational health
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