Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

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dc.contributor.author Jelenkovic, Aline
dc.contributor.author Sund, Reijo
dc.contributor.author Yokoyama, Yoshie
dc.contributor.author Latvala, Antti
dc.contributor.author Sugawara, Masumi
dc.contributor.author Tanaka, Mami
dc.contributor.author Matsumoto, Satoko
dc.contributor.author Freitas, Duarte L.
dc.contributor.author Maia, Jose Antonio
dc.contributor.author Knafo-Noam, Ariel
dc.contributor.author Mankuta, David
dc.contributor.author Abramson, Lior
dc.contributor.author Ji, Fuling
dc.contributor.author Ning, Feng
dc.contributor.author Pang, Zengchang
dc.contributor.author Rebato, Esther
dc.contributor.author Saudino, Kimberly J.
dc.contributor.author Cutler, Tessa L.
dc.contributor.author Hopper, John L.
dc.contributor.author Ullemar, Vilhelmina
dc.contributor.author Almqvist, Catarina
dc.contributor.author Magnusson, Patrik K. E.
dc.contributor.author Cozen, Wendy
dc.contributor.author Hwang, Amie E.
dc.contributor.author Mack, Thomas M.
dc.contributor.author Nelson, Tracy L.
dc.contributor.author Whitfield, Keith E.
dc.contributor.author Sung, Joohon
dc.contributor.author Kim, Jina
dc.contributor.author Lee, Jooyeon
dc.contributor.author Lee, Sooji
dc.contributor.author Llewellyn, Clare H.
dc.contributor.author Fisher, Abigail
dc.contributor.author Medda, Emanuela
dc.contributor.author Nistico, Lorenza
dc.contributor.author Toccaceli, Virgilia
dc.contributor.author Baker, Laura A.
dc.contributor.author Tuvblad, Catherine
dc.contributor.author Corley, Robin P.
dc.contributor.author Huibregtse, Brooke M.
dc.contributor.author Derom, Catherine A.
dc.contributor.author Vlietinck, Robert F.
dc.contributor.author Loos, Ruth J. F.
dc.contributor.author Burt, S. Alexandra
dc.contributor.author Klump, Kelly L.
dc.contributor.author Silberg, Judy L.
dc.contributor.author Maes, Hermine H.
dc.contributor.author Krueger, Robert F.
dc.contributor.author McGue, Matt
dc.contributor.author Pahlen, Shandell
dc.contributor.author Gatz, Margaret
dc.contributor.author Butler, David A.
dc.contributor.author Harris, Jennifer R.
dc.contributor.author Brandt, Ingunn
dc.contributor.author Nilsen, Thomas S.
dc.contributor.author Harden, K. Paige
dc.contributor.author Tucker-Drob, Elliot M.
dc.contributor.author Franz, Carol E.
dc.contributor.author Kremen, William S.
dc.contributor.author Lyons, Michael J.
dc.contributor.author Lichtenstein, Paul
dc.contributor.author Bartels, Meike
dc.contributor.author van Beijsterveldt, Catharina E. M.
dc.contributor.author Willemsen, Gonneke
dc.contributor.author Oncel, Sevgi Y.
dc.contributor.author Aliev, Fazil
dc.contributor.author Jeong, Hoe-Uk
dc.contributor.author Hur, Yoon-Mi
dc.contributor.author Turkheimer, Eric
dc.contributor.author Boomsma, Dorret
dc.contributor.author Srensen, Thorkild I. A.
dc.contributor.author Kaprio, Jaakko
dc.contributor.author Silventoinen, Karri
dc.date.accessioned 2020-09-17T06:41:01Z
dc.date.available 2020-09-17T06:41:01Z
dc.date.issued 2020-05-14
dc.identifier.citation Jelenkovic , A , Sund , R , Yokoyama , Y , Latvala , A , Sugawara , M , Tanaka , M , Matsumoto , S , Freitas , D L , Maia , J A , Knafo-Noam , A , Mankuta , D , Abramson , L , Ji , F , Ning , F , Pang , Z , Rebato , E , Saudino , K J , Cutler , T L , Hopper , J L , Ullemar , V , Almqvist , C , Magnusson , P K E , Cozen , W , Hwang , A E , Mack , T M , Nelson , T L , Whitfield , K E , Sung , J , Kim , J , Lee , J , Lee , S , Llewellyn , C H , Fisher , A , Medda , E , Nistico , L , Toccaceli , V , Baker , L A , Tuvblad , C , Corley , R P , Huibregtse , B M , Derom , C A , Vlietinck , R F , Loos , R J F , Burt , S A , Klump , K L , Silberg , J L , Maes , H H , Krueger , R F , McGue , M , Pahlen , S , Gatz , M , Butler , D A , Harris , J R , Brandt , I , Nilsen , T S , Harden , K P , Tucker-Drob , E M , Franz , C E , Kremen , W S , Lyons , M J , Lichtenstein , P , Bartels , M , van Beijsterveldt , C E M , Willemsen , G , Oncel , S Y , Aliev , F , Jeong , H-U , Hur , Y-M , Turkheimer , E , Boomsma , D , Srensen , T I A , Kaprio , J & Silventoinen , K 2020 , ' Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education ' , Scientific Reports , vol. 10 , no. 1 , 7974 . https://doi.org/10.1038/s41598-020-64883-8
dc.identifier.other PURE: 144616617
dc.identifier.other PURE UUID: 565497eb-b2d4-4e45-a685-731babe462e6
dc.identifier.other WOS: 000560040700031
dc.identifier.other ORCID: /0000-0003-1759-3079/work/80576252
dc.identifier.other ORCID: /0000-0002-6268-8117/work/80577203
dc.identifier.uri http://hdl.handle.net/10138/319440
dc.description.abstract Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject GENOME-WIDE ASSOCIATION
dc.subject MATERNAL EDUCATION
dc.subject TWINS
dc.subject GROWTH
dc.subject HERITABILITY
dc.subject CHILDREN
dc.subject PROJECT
dc.subject LOCI
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.contributor.organization University of Helsinki
dc.contributor.organization Department of Social Research (2010-2017)
dc.contributor.organization Institute of Criminology and Legal Policy
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Helsinki Inequality Initiative (INEQ)
dc.contributor.organization Population Research Unit (PRU)
dc.contributor.organization Center for Population, Health and Society
dc.contributor.organization Sociology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41598-020-64883-8
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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