Influence of family history on risk of second primary cancers and survival in patients with squamous cell skin cancer

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Chattopadhyay , S , Zheng , G , Hemminki , A , Försti , A , Sundquist , K , Sundquist , J & Hemminki , K 2020 , ' Influence of family history on risk of second primary cancers and survival in patients with squamous cell skin cancer ' , British Journal of Dermatology , vol. 183 , no. 3 , pp. 488-494 . https://doi.org/10.1111/bjd.18809

Title: Influence of family history on risk of second primary cancers and survival in patients with squamous cell skin cancer
Author: Chattopadhyay, S.; Zheng, G.; Hemminki, A.; Försti, A.; Sundquist, K.; Sundquist, J.; Hemminki, K.
Contributor: University of Helsinki, Department of Oncology
Date: 2020-09
Language: eng
Number of pages: 7
Belongs to series: British Journal of Dermatology
ISSN: 0007-0963
URI: http://hdl.handle.net/10138/319502
Abstract: Summary Background Patients with squamous cell skin cancer (SCC) have an excellent prognosis but second primary cancers (SPCs) weaken survival prospects. Family history is a known risk factor for cancer but whether it is a risk factor for SPC in patients with SCC is not known. Objectives To quantify the risk of family history on SPCs in patients with SCC and estimate survival probabilities of patients with SPCs depending on family history. Methods With 13 945 histologically verified SCCs, relative risks (RRs) were estimated for family history using a generalized regression model. For survival analysis, hazard ratios (HRs) were assessed using a multivariable Cox proportional-hazards model. Results Family history of invasive SCC increased risk of second invasive SCC [RR = 42·92, 95% confidence interval (CI) 33·69?50·32] compared with risk without family history (RR 19·12, 95% CI 17·88?21·08). Family history of any nonskin cancer in invasive SCC increased risk of the same cancers to be diagnosed as SPC (RRFH = 1·48, 95% CI 1·35?1·61 vs. RRno FH = 1·40, 95% CI 1·32?1·48); significant increases were observed for seven different nonskin cancers. Most results were replicated for in situ SCC. SPC was deleterious for survival irrespective of family history; HR for patients with SPC was 4·28 (95% CI 3·83?4·72) vs. those without SPC (1·04). Conclusions Family history of nonskin cancer was associated with approximately a doubling of risk for SPCs in patients with SCC. SPC increases the death rate in patients with SCC 3?4 times, irrespective of family history. Taking family history into account at SCC diagnosis may help prevention or early detection of SPCs. What's already known about this topic? Second primary cancers (SPCs) are frequently diagnosed in patients with invasive and in situ squamous cell carcinoma (SCC); some epidemiological studies suggest a link to immune dysfunction. Family history of cancer is a risk factor for practically all first primary cancers but whether it also influences risk of SPCs in patients with SCC is not known. The possible influence of family history on survival in patients with SCC remains to be established.
Subject: 3122 Cancers
IN-SITU
CARCINOMA
TRANSPLANTATION
MORTALITY
TRENDS
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