Subtype of atrial fibrillation and the outcome of transcatheter aortic valve replacement: The FinnValve Study

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Jaakkola , J , Jaakkola , S , Airaksinen , K E J , Husso , A , Juvonen , T , Laine , M , Virtanen , M , Maaranen , P , Niemelä , M , Mäkikallio , T , Savontaus , M , Tauriainen , T , Valtola , A , Vento , A , Eskola , M , Raivio , P & Biancari , F 2020 , ' Subtype of atrial fibrillation and the outcome of transcatheter aortic valve replacement: The FinnValve Study ' , PLoS One , vol. 15 , no. 9 , 0238953 . https://doi.org/10.1371/journal.pone.0238953

Title: Subtype of atrial fibrillation and the outcome of transcatheter aortic valve replacement: The FinnValve Study
Author: Jaakkola, Jussi; Jaakkola, Samuli; Airaksinen, K. E. Juhani; Husso, Annastiina; Juvonen, Tatu; Laine, Mika; Virtanen, Marko; Maaranen, Pasi; Niemelä, Matti; Mäkikallio, Timo; Savontaus, Mikko; Tauriainen, Tuomas; Valtola, Antti; Vento, Antti; Eskola, Markku; Raivio, Peter; Biancari, Fausto
Other contributor: University of Helsinki, Kuopio University Hospital
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Department of Surgery
University of Helsinki, HUS Heart and Lung Center





Date: 2020-09-11
Language: eng
Number of pages: 12
Belongs to series: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0238953
URI: http://hdl.handle.net/10138/319504
Abstract: Whether the subtype of atrial fibrillation affects outcomes after transcatheter aortic valve replacement for aortic stenosis is unclear. The nationwide FinnValve registry included 2130 patients who underwent primary after transcatheter aortic valve replacement for aortic stenosis during 2008–2017. Altogether, 281 (13.2%) patients had pre-existing paroxysmal atrial fibrillation, 651 (30.6%) had pre-existing non-paroxysmal atrial fibrillation and 160 (7.5%) were diagnosed with new-onset atrial fibrillation during the index hospitalization. The median follow-up was 2.4 (interquartile range: 1.6–3.8) years. Paroxysmal atrial fibrillation did not affect 30-day or overall mortality (p-values >0.05). Non-paroxysmal atrial fibrillation demonstrated an increased risk of overall mortality (hazard ratio: 1.61, 95% confidence interval: 1.35–1.92; p0.05). In conclusion, non-paroxysmal atrial fibrillation and new-onset atrial fibrillation are associated with increased mortality after transcatheter aortic valve replacement for aortic stenosis, whereas paroxysmal atrial fibrillation has no effect on mortality. These findings suggest that non-paroxysmal atrial fibrillation rather than paroxysmal atrial fibrillation may be associated with structural cardiac damage which is of prognostic significance in patients with aortic stenosis undergoing transcatheter aortic valve replacement.
Subject: 3126 Surgery, anesthesiology, intensive care, radiology
CLINICAL-OUTCOMES
INCREASED MORTALITY
IMPLANTATION
IMPACT
STENOSIS
MANAGEMENT
RISK
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