Correlates and genetics of self-reported sleep and awake bruxism in a nationwide twin cohort

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Ahlberg , J , Piirtola , M , Lobbezoo , F , Manfredini , D , Korhonen , T , Aarab , G , Hublin , C & Kaprio , J 2020 , ' Correlates and genetics of self-reported sleep and awake bruxism in a nationwide twin cohort ' , Journal of Oral Rehabilitation , vol. 47 , no. 9 , pp. 1110-1119 . https://doi.org/10.1111/joor.13042

Title: Correlates and genetics of self-reported sleep and awake bruxism in a nationwide twin cohort
Author: Ahlberg, Jari; Piirtola, Maarit; Lobbezoo, Frank; Manfredini, Daniele; Korhonen, Tellervo; Aarab, Ghizlane; Hublin, Christer; Kaprio, Jaakko
Contributor organization: HUS Head and Neck Center
Clinicum
Department of Oral and Maxillofacial Diseases
University of Helsinki
Genetic Epidemiology
Institute for Molecular Medicine Finland
Helsinki Institute of Life Science HiLIFE
Department of Public Health
Faculty of Medicine
Date: 2020-09
Language: eng
Number of pages: 10
Belongs to series: Journal of Oral Rehabilitation
ISSN: 0305-182X
DOI: https://doi.org/10.1111/joor.13042
URI: http://hdl.handle.net/10138/319554
Abstract: Background Sleep bruxism (SB) and awake bruxism (AB) have been considered different entities, although co-occurrence between them has been shown. While genetic factors have a marked influence on phenotypic variance in liability to SB, this remains unclear for AB. Aim To examine the degree of co-occurrence of SB and AB, and whether they have common correlates and also twin similarity of SB and AB bruxism traits by zygosity and sex. Methods A questionnaire was mailed to all twins born 1945-1957 in Finland in 2012 (n = 11 766). Age and sex adjusted logistic regression models were used. Twin similarity was assessed using polychoric correlations, and crosstwin-crosstrait correlations were computed. Results The response rate was 72% (n = 8410). Any SB was reported by 14.8% and >= 3 nights weekly by 5.0%. Percentages for any AB were 18.4% and 6.3%, respectively. There was substantial co-occurrence (29.5%) between SB and AB, and several shared correlates were found. For SB, the polychoric intra-class correlation was 0.366 in monozygotic (MZ) and 0.200 in dizygotic (DZ) pairs, without gender difference. A twofold crosstwin-crosstrait correlation was observed in MZ twins compared to DZ twins. Conclusions The risk factor profiles of SB and AB were largely but not entirely similar. The higher correlation in MZ than in DZ pairs suggests the influence of genetic factors on both SB and AB. The higher crosstwin-crosstrait correlation in MZ than in DZ pairs suggests some degree of genetic influences shared by SB and AB.
Subject: awake bruxism
genetic epidemiology
sleep bruxism
twins
RISK-FACTORS
ADULTS
ASSOCIATION
ETIOLOGY
313 Dentistry
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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