Exercise training improves adipose tissue metabolism and vasculature regardless of baseline glucose tolerance and sex

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http://hdl.handle.net/10138/319594

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Honkala , S M , Motiani , P , Kivelä , R , Hemanthakumar , K A , Tolvanen , E , Motiani , K K , Eskelinen , J-J , Virtanen , K A , Kemppainen , J , Heiskanen , M A , Loyttyniemi , E , Nuutila , P , Kalliokoski , K K & Hannukainen , J C 2020 , ' Exercise training improves adipose tissue metabolism and vasculature regardless of baseline glucose tolerance and sex ' , BMJ Open Diabetes Research & Care , vol. 8 , no. 1 , 000830 . https://doi.org/10.1136/bmjdrc-2019-000830

Title: Exercise training improves adipose tissue metabolism and vasculature regardless of baseline glucose tolerance and sex
Author: Honkala, Sanna Maria; Motiani, Piryanka; Kivelä, Riikka; Hemanthakumar, Karthik Amudhala; Tolvanen, Erik; Motiani, Kumail Kumar; Eskelinen, Jari-Joonas; Virtanen, Kirsi A.; Kemppainen, Jukka; Heiskanen, Marja Anneli; Loyttyniemi, Eliisa; Nuutila, Pirjo; Kalliokoski, Kari K.; Hannukainen, Jarna Christina
Contributor: University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
University of Helsinki, Kivelä Lab
University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
Date: 2020-01
Language: eng
Number of pages: 14
Belongs to series: BMJ Open Diabetes Research & Care
ISSN: 2052-4897
URI: http://hdl.handle.net/10138/319594
Abstract: Introduction We investigated the effects of a supervised progressive sprint interval training (SIT) and moderate-intensity continuous training (MICT) on adipocyte morphology and adipose tissue metabolism and function; we also tested whether the responses were similar regardless of baseline glucose tolerance and sex. Research design and methods 26 insulin-resistant (IR) and 28 healthy participants were randomized into 2-week-long SIT (4-6x30 s at maximum effort) and MICT (40-60 min at 60% of maximal aerobic capacity (VO2peak)). Insulin-stimulated glucose uptake and fasting-free fatty acid uptake in visceral adipose tissue (VAT), abdominal and femoral subcutaneous adipose tissues (SATs) were quantified with positron emission tomography. Abdominal SAT biopsies were collected to determine adipocyte morphology, gene expression markers of lipolysis, glucose and lipid metabolism and inflammation. Results Training increased glucose uptake in VAT (p
Subject: exercise metabolism
adipose tissue metabolism
insulin resistance
positron emission tomography
HIGH-INTENSITY INTERVAL
FATTY-ACID UPTAKE
HUMAN SKELETAL-MUSCLE
TERM SPRINT INTERVAL
MITOCHONDRIAL BIOGENESIS
INSULIN SENSITIVITY
AUTONOMIC FUNCTION
OBESE INDIVIDUALS
ADIPOCYTE SIZE
WEIGHT-LOSS
3121 General medicine, internal medicine and other clinical medicine
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