The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study

Show simple item record Lehikoinen, Anni Voutilainen, Raimo Romppanen, Jarkko Heinonen, Seppo 2020-09-27T03:24:48Z 2020-09-27T03:24:48Z 2020-09-25
dc.identifier.citation BMC Pregnancy and Childbirth. 2020 Sep 25;20(1):562
dc.description.abstract Abstract Background The purpose of this study was to determine whether first trimester trisomy screening (FTS) parameters are affected by alcohol and drug use. Methods A routine combined FTS including measurements of maternal serum levels of free β-human chorionic gonadotropin subunit (free β-hCG) and pregnancy-associated plasma protein A (PAPP-A) were measured at 9–11 weeks of gestation, and fetal nuchal translucency thickness (NTT) at 11–13 weeks of gestation. In total 544 women with singleton pregnancies [71 alcohol and drug abusers, 88 smokers, 168 non-smokers delivering a small for gestational age (SGA) child, and 217 unexposed control women] were assessed. Results Free β-hCG levels were higher in alcohol and drug abusing than in unexposed pregnant women [mean 1.5 vs. 1.2 multiples of medians (MoM); P = 0.013]. However, stepwise multiple linear regression analyses suggested that smoking could explain increased free β-hCG. Additionally, we observed lower PAPP-A levels in the smoking mothers (0.9 vs. 1.2 MoM; P = 0.045) and in those giving birth to an SGA child compared to the controls (1.1 vs.. 1.2 MoM; P < 0.001). Fetal NTT did not differ significantly between any of the groups. Conclusions The present study shows increased free β-hCG levels in alcohol and drug abusers, but maternal smoking may explain the result. Maternal serum PAPP-A levels were lower in smoking than non-smoking mothers, and in mothers delivering an SGA child. However, FTS parameters (PAPP-A, free β-hCG and NTT) seem not to be applicable for the use as alcohol biomarkers because of their clear overlap between alcohol abusers and healthy controls.
dc.publisher BioMed Central
dc.subject First trimester screening
dc.subject PAPP-A
dc.subject free β-hCG
dc.subject nuchal translucency
dc.subject alcohol
dc.subject smoking
dc.subject small for gestational age
dc.title The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study 2020-09-27T03:24:48Z
dc.language.rfc3066 en
dc.rights.holder The Author(s)

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