Polygenic prediction of the risk of perinatal depressive symptoms

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Rantalainen , V , Binder , E B , Lahti-Pulkkinen , M , Czamara , D , Laivuori , H , Villa , P , Girchenko , P , Kvist , T , Hämäläinen , E , Kajantie , E , Lahti , J & Räikkönen , K 2020 , ' Polygenic prediction of the risk of perinatal depressive symptoms ' , Depression and Anxiety , vol. 37 , no. 9 , pp. 862-875 . https://doi.org/10.1002/da.23066

Title: Polygenic prediction of the risk of perinatal depressive symptoms
Author: Rantalainen, Ville; Binder, Elisabeth B.; Lahti-Pulkkinen, Marius; Czamara, Darina; Laivuori, Hannele; Villa, Pia; Girchenko, Polina; Kvist, Tuomas; Hämäläinen, Esa; Kajantie, Eero; Lahti, Jari; Räikkönen, Katri
Contributor organization: Department of Psychology and Logopedics
Developmental Psychology Research Group
Faculty of Medicine
University of Helsinki
Behavioural Sciences
HUS Gynecology and Obstetrics
Genomics of Neurological and Neuropsychiatric Disorders
Institute for Molecular Medicine Finland
University Management
Pregnancy and Genes
Department of Medical and Clinical Genetics
Helsinki University Hospital Area
Helsinki Institute of Life Science HiLIFE
Department of Obstetrics and Gynecology
HUS Children and Adolescents
Date: 2020-09
Language: eng
Number of pages: 14
Belongs to series: Depression and Anxiety
ISSN: 1091-4269
DOI: https://doi.org/10.1002/da.23066
URI: http://hdl.handle.net/10138/319670
Abstract: Background Perinatal depression carries adverse effects on maternal health and child development, but genetic underpinnings remain unclear. We investigated the polygenic risk of perinatal depressive symptoms. Methods About 742 women from the prospective Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction cohort were genotyped and completed the Center for Epidemiologic Studies Depression scale 14 times during the prenatal period and twice up to 12 months postpartum. Polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and cross-disorder were calculated using multiplep-value thresholds. Results Polygenic risk scores for major depressive disorder, schizophrenia, and cross-disorder, but not bipolar disorder, were associated with higher prenatal and postpartum depressive symptoms (0.8%-1% increase per one standard deviation increase in polygenic risk scores). Prenatal depressive symptoms accounted for and mediated the associations between the polygenic risk scores and postpartum depressive symptoms (effect size proportions-mediated: 52.2%-88.0%). Further, the polygenic risk scores were associated with 1.24-1.45-fold odds to belong to the group displaying consistently high compared with consistently low depressive symptoms through out the prenatal and postpartum periods. Conclusions Polygenic risk scores for major depressive disorder, schizophrenia, and cross-disorder in non-perinatal populations generalize to perinatal depressive symptoms and may afford to identify women for timely preventive interventions.
mood disorders
pregnancy and postpartum
515 Psychology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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