The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study

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http://hdl.handle.net/10138/319676

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Lehikoinen , A , Voutilainen , R , Romppanen , J & Heinonen , S 2020 , ' The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study ' , BMC Pregnancy and Childbirth , vol. 20 , no. 1 , 562 . https://doi.org/10.1186/s12884-020-03171-9

Title: The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study
Author: Lehikoinen, Anni; Voutilainen, Raimo; Romppanen, Jarkko; Heinonen, Seppo
Contributor: University of Helsinki, HUS Gynecology and Obstetrics
Date: 2020-09-25
Language: eng
Number of pages: 7
Belongs to series: BMC Pregnancy and Childbirth
ISSN: 1471-2393
URI: http://hdl.handle.net/10138/319676
Abstract: Background: The purpose of this study was to determine whether first trimester trisomy screening (FTS) parameters are affected by alcohol and drug use. Methods: A routine combined FTS including measurements of maternal serum levels of free beta-human chorionic gonadotropin subunit (free beta-hCG) and pregnancy-associated plasma protein A (PAPP-A) were measured at 9-11 weeks of gestation, and fetal nuchal translucency thickness (NTT) at 11-13 weeks of gestation. In total 544 women with singleton pregnancies [71 alcohol and drug abusers, 88 smokers, 168 non-smokers delivering a small for gestational age (SGA) child, and 217 unexposed control women] were assessed. Results: Free beta-hCG levels were higher in alcohol and drug abusing than in unexposed pregnant women [mean 1.5 vs. 1.2 multiples of medians (MoM); P=0.013]. However, stepwise multiple linear regression analyses suggested that smoking could explain increased free beta-hCG. Additionally, we observed lower PAPP-A levels in the smoking mothers (0.9 vs. 1.2 MoM; P=0.045) and in those giving birth to an SGA child compared to the controls (1.1 vs.. 1.2 MoM; P Conclusions: The present study shows increased free beta-hCG levels in alcohol and drug abusers, but maternal smoking may explain the result. Maternal serum PAPP-A levels were lower in smoking than non-smoking mothers, and in mothers delivering an SGA child. However, FTS parameters (PAPP-A, free beta-hCG and NTT) seem not to be applicable for the use as alcohol biomarkers because of their clear overlap between alcohol abusers and healthy controls.
Subject: 3123 Gynaecology and paediatrics
First trimester screening
PAPP-A
free β-hCG
NUCHAL TRANSLUCENCY
alcohol
SMOKING
Small for gestational age
First trimester screening
PAPP-A
free beta-hCG
nuchal translucency
alcohol
smoking
small for gestational age
HUMAN CHORIONIC-GONADOTROPIN
PLASMA-PROTEIN-A
BIOCHEMICAL MARKERS
NUCHAL TRANSLUCENCY
BETA
PREGNANCY
BIOMARKERS
EXPOSURE
ETHANOL
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