The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study

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dc.contributor.author Lehikoinen, Anni
dc.contributor.author Voutilainen, Raimo
dc.contributor.author Romppanen, Jarkko
dc.contributor.author Heinonen, Seppo
dc.date.accessioned 2020-09-29T05:41:01Z
dc.date.available 2020-09-29T05:41:01Z
dc.date.issued 2020-09-25
dc.identifier.citation Lehikoinen , A , Voutilainen , R , Romppanen , J & Heinonen , S 2020 , ' The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study ' , BMC Pregnancy and Childbirth , vol. 20 , no. 1 , 562 . https://doi.org/10.1186/s12884-020-03171-9
dc.identifier.other PURE: 145348663
dc.identifier.other PURE UUID: 22a82c30-8834-4b7c-bafa-0a53a2b62690
dc.identifier.other WOS: 000576297400001
dc.identifier.uri http://hdl.handle.net/10138/319676
dc.description.abstract Background: The purpose of this study was to determine whether first trimester trisomy screening (FTS) parameters are affected by alcohol and drug use. Methods: A routine combined FTS including measurements of maternal serum levels of free beta-human chorionic gonadotropin subunit (free beta-hCG) and pregnancy-associated plasma protein A (PAPP-A) were measured at 9-11 weeks of gestation, and fetal nuchal translucency thickness (NTT) at 11-13 weeks of gestation. In total 544 women with singleton pregnancies [71 alcohol and drug abusers, 88 smokers, 168 non-smokers delivering a small for gestational age (SGA) child, and 217 unexposed control women] were assessed. Results: Free beta-hCG levels were higher in alcohol and drug abusing than in unexposed pregnant women [mean 1.5 vs. 1.2 multiples of medians (MoM); P=0.013]. However, stepwise multiple linear regression analyses suggested that smoking could explain increased free beta-hCG. Additionally, we observed lower PAPP-A levels in the smoking mothers (0.9 vs. 1.2 MoM; P=0.045) and in those giving birth to an SGA child compared to the controls (1.1 vs.. 1.2 MoM; P Conclusions: The present study shows increased free beta-hCG levels in alcohol and drug abusers, but maternal smoking may explain the result. Maternal serum PAPP-A levels were lower in smoking than non-smoking mothers, and in mothers delivering an SGA child. However, FTS parameters (PAPP-A, free beta-hCG and NTT) seem not to be applicable for the use as alcohol biomarkers because of their clear overlap between alcohol abusers and healthy controls. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof BMC Pregnancy and Childbirth
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3123 Gynaecology and paediatrics
dc.subject First trimester screening
dc.subject PAPP-A
dc.subject free β-hCG
dc.subject NUCHAL TRANSLUCENCY
dc.subject alcohol
dc.subject SMOKING
dc.subject Small for gestational age
dc.subject First trimester screening
dc.subject PAPP-A
dc.subject free beta-hCG
dc.subject nuchal translucency
dc.subject alcohol
dc.subject smoking
dc.subject small for gestational age
dc.subject HUMAN CHORIONIC-GONADOTROPIN
dc.subject PLASMA-PROTEIN-A
dc.subject BIOCHEMICAL MARKERS
dc.subject NUCHAL TRANSLUCENCY
dc.subject BETA
dc.subject PREGNANCY
dc.subject BIOMARKERS
dc.subject EXPOSURE
dc.subject ETHANOL
dc.title The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study en
dc.type Article
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s12884-020-03171-9
dc.relation.issn 1471-2393
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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