Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection

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http://hdl.handle.net/10138/319711

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Mantula , P , Tietavainen , J , Clement , J , Niemelä , O , Pörsti , I , Vaheri , A , Mustonen , J , Mäkelä , S & Outinen , T 2020 , ' Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection ' , Pathogens , vol. 9 , no. 8 , 615 . https://doi.org/10.3390/pathogens9080615

Title: Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection
Author: Mantula, Paula; Tietavainen, Johanna; Clement, Jan; Niemelä, Onni; Pörsti, Ilkka; Vaheri, Antti; Mustonen, Jukka; Mäkelä, Satu; Outinen, Tuula
Contributor: University of Helsinki, Medicum
Date: 2020-08
Language: eng
Number of pages: 10
Belongs to series: Pathogens
ISSN: 2076-0817
URI: http://hdl.handle.net/10138/319711
Abstract: Transient proteinuria and acute kidney injury (AKI) are characteristics of Puumala virus (PUUV) infection. Albuminuria peaks around the fifth day and associates with AKI severity. To evaluate albuminuria disappearance rate, we quantified albumin excretion at different time points after the fever onset. The study included 141 consecutive patients hospitalized due to acute PUUV infection in Tampere University Hospital, Finland. Timed overnight albumin excretion (cU-Alb) was measured during the acute phase in 133 patients, once or twice during the convalescent phase within three months in 94 patients, and at six months in 36 patients. During hospitalization, 30% of the patients had moderately increased albuminuria (cU-Alb 20-200 mu g/min), while 57% presented with severely increased albuminuria (cU-Alb >200 mu g/min). Median cU-Alb was 311 mu g/min (range 2.2-6460)
Subject: albuminuria
proteinuria
Puumala virus
hantavirus
acute kidney injury
hemorrhagic fever with renal syndrome
HFRS
INDUCED HEMORRHAGIC-FEVER
NEPHROPATHIA-EPIDEMICA
RENAL SYNDROME
PROTEINURIA
SEVERITY
DISEASE
PATHOGENESIS
PREDICTS
NECROSIS
11832 Microbiology and virology
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