Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis

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Almangush , A , Pirinen , M , Youssef , O , Mäkitie , A A & Leivo , I 2020 , ' Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis ' , Head & Neck , vol. 42 , no. 10 , pp. 3002-3017 . https://doi.org/10.1002/hed.26344

Title: Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis
Author: Almangush, Alhadi; Pirinen, Matti; Youssef, Omar; Mäkitie, Antti A.; Leivo, Ilmo
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Department of Pathology
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, University of Turku
Date: 2020-10
Language: eng
Number of pages: 16
Belongs to series: Head & Neck
ISSN: 1043-3074
URI: http://hdl.handle.net/10138/319724
Abstract: The eighth edition of the American Joint Committee on Cancer (AJCC8) staging manual has major changes in oral squamous cell carcinoma (OSCC). We searched PubMed, OvidMedline, Scopus, and Web of Science for studies that examined the performance of AJCC8 in OSCC. A total of 40 808 patients were included in the studies of our meta-analysis. A hazard ratio (HR) of 1.87 (95%CI 1.78-1.96) was seen for stage II, 2.65 (95%CI 2.51-2.80) for stage III, 3.46 (95%CI 3.31-3.61) for stage IVa, and 7.09 (95%CI 4.85-10.36) for stage IVb. A similar gradual increase in risk was noted for the N classification. For the T classification, however, there was a less clear variation in risk between T3 and T4. AJCC8 provides a good risk stratification for OSCC. Future research should examine the proposals introduced in the published studies to further improve the performance of AJCC8.
Subject: eighth edition American Joint Committee on Cancer (AJCC 8)
depth of invasion (DOI)
extranodal extension
N classification
oral squamous cell carcinoma (OSCC)
prognosis
T classification
TNM stage
WORST PATTERN
LYMPH-NODES
EDITION
TONGUE
INVASION
DEPTH
7TH
HEAD
VALIDATION
PROGNOSIS
111 Mathematics
3125 Otorhinolaryngology, ophthalmology
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