Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis

Näytä kaikki kuvailutiedot



Pysyväisosoite

http://hdl.handle.net/10138/319724

Lähdeviite

Almangush , A , Pirinen , M , Youssef , O , Mäkitie , A A & Leivo , I 2020 , ' Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis ' , Head & Neck , vol. 42 , no. 10 , pp. 3002-3017 . https://doi.org/10.1002/hed.26344

Julkaisun nimi: Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis
Tekijä: Almangush, Alhadi; Pirinen, Matti; Youssef, Omar; Mäkitie, Antti A.; Leivo, Ilmo
Tekijän organisaatio: HUS Head and Neck Center
Department of Pathology
Research Program in Systems Oncology
Centre of Excellence in Complex Disease Genetics
Statistical and population genetics
Department of Mathematics and Statistics
Institute for Molecular Medicine Finland
Biostatistics Helsinki
Department of Public Health
Department of Ophthalmology and Otorhinolaryngology
Päiväys: 2020-10
Kieli: eng
Sivumäärä: 16
Kuuluu julkaisusarjaan: Head & Neck
ISSN: 1043-3074
DOI-tunniste: https://doi.org/10.1002/hed.26344
URI: http://hdl.handle.net/10138/319724
Tiivistelmä: The eighth edition of the American Joint Committee on Cancer (AJCC8) staging manual has major changes in oral squamous cell carcinoma (OSCC). We searched PubMed, OvidMedline, Scopus, and Web of Science for studies that examined the performance of AJCC8 in OSCC. A total of 40 808 patients were included in the studies of our meta-analysis. A hazard ratio (HR) of 1.87 (95%CI 1.78-1.96) was seen for stage II, 2.65 (95%CI 2.51-2.80) for stage III, 3.46 (95%CI 3.31-3.61) for stage IVa, and 7.09 (95%CI 4.85-10.36) for stage IVb. A similar gradual increase in risk was noted for the N classification. For the T classification, however, there was a less clear variation in risk between T3 and T4. AJCC8 provides a good risk stratification for OSCC. Future research should examine the proposals introduced in the published studies to further improve the performance of AJCC8.
Avainsanat: eighth edition American Joint Committee on Cancer (AJCC 8)
depth of invasion (DOI)
extranodal extension
N classification
oral squamous cell carcinoma (OSCC)
prognosis
T classification
TNM stage
WORST PATTERN
LYMPH-NODES
EDITION
TONGUE
INVASION
DEPTH
7TH
HEAD
VALIDATION
PROGNOSIS
111 Mathematics
3125 Otorhinolaryngology, ophthalmology
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


Tiedostot

Latausmäärä yhteensä: Ladataan...

Tiedosto(t) Koko Formaatti Näytä
hed.26344.pdf 1.708MB PDF Avaa tiedosto

Viite kuuluu kokoelmiin:

Näytä kaikki kuvailutiedot