Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis

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Almangush , A , Pirinen , M , Youssef , O , Mäkitie , A A & Leivo , I 2020 , ' Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis ' , Head & Neck , vol. 42 , no. 10 , pp. 3002-3017 . https://doi.org/10.1002/hed.26344

Titel: Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis
Författare: Almangush, Alhadi; Pirinen, Matti; Youssef, Omar; Mäkitie, Antti A.; Leivo, Ilmo
Upphovmannens organisation: HUS Head and Neck Center
Department of Pathology
Research Program in Systems Oncology
Centre of Excellence in Complex Disease Genetics
Statistical and population genetics
Department of Mathematics and Statistics
Institute for Molecular Medicine Finland
Biostatistics Helsinki
Department of Public Health
Department of Ophthalmology and Otorhinolaryngology
Datum: 2020-10
Språk: eng
Sidantal: 16
Tillhör serie: Head & Neck
ISSN: 1043-3074
DOI: https://doi.org/10.1002/hed.26344
Permanenta länken (URI): http://hdl.handle.net/10138/319724
Abstrakt: The eighth edition of the American Joint Committee on Cancer (AJCC8) staging manual has major changes in oral squamous cell carcinoma (OSCC). We searched PubMed, OvidMedline, Scopus, and Web of Science for studies that examined the performance of AJCC8 in OSCC. A total of 40 808 patients were included in the studies of our meta-analysis. A hazard ratio (HR) of 1.87 (95%CI 1.78-1.96) was seen for stage II, 2.65 (95%CI 2.51-2.80) for stage III, 3.46 (95%CI 3.31-3.61) for stage IVa, and 7.09 (95%CI 4.85-10.36) for stage IVb. A similar gradual increase in risk was noted for the N classification. For the T classification, however, there was a less clear variation in risk between T3 and T4. AJCC8 provides a good risk stratification for OSCC. Future research should examine the proposals introduced in the published studies to further improve the performance of AJCC8.
Subject: eighth edition American Joint Committee on Cancer (AJCC 8)
depth of invasion (DOI)
extranodal extension
N classification
oral squamous cell carcinoma (OSCC)
prognosis
T classification
TNM stage
WORST PATTERN
LYMPH-NODES
EDITION
TONGUE
INVASION
DEPTH
7TH
HEAD
VALIDATION
PROGNOSIS
111 Mathematics
3125 Otorhinolaryngology, ophthalmology
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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