Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis

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dc.contributor.author Almangush, Alhadi
dc.contributor.author Pirinen, Matti
dc.contributor.author Youssef, Omar
dc.contributor.author Mäkitie, Antti A.
dc.contributor.author Leivo, Ilmo
dc.date.accessioned 2020-09-30T13:10:02Z
dc.date.available 2020-09-30T13:10:02Z
dc.date.issued 2020-10
dc.identifier.citation Almangush , A , Pirinen , M , Youssef , O , Mäkitie , A A & Leivo , I 2020 , ' Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis ' , Head & Neck , vol. 42 , no. 10 , pp. 3002-3017 . https://doi.org/10.1002/hed.26344
dc.identifier.other PURE: 140595217
dc.identifier.other PURE UUID: 52a69e1b-374d-426d-a983-a57ccef42f98
dc.identifier.other WOS: 000540466000001
dc.identifier.other ORCID: /0000-0002-1664-1350/work/81358332
dc.identifier.other ORCID: /0000-0002-1827-9156/work/81360394
dc.identifier.uri http://hdl.handle.net/10138/319724
dc.description.abstract The eighth edition of the American Joint Committee on Cancer (AJCC8) staging manual has major changes in oral squamous cell carcinoma (OSCC). We searched PubMed, OvidMedline, Scopus, and Web of Science for studies that examined the performance of AJCC8 in OSCC. A total of 40 808 patients were included in the studies of our meta-analysis. A hazard ratio (HR) of 1.87 (95%CI 1.78-1.96) was seen for stage II, 2.65 (95%CI 2.51-2.80) for stage III, 3.46 (95%CI 3.31-3.61) for stage IVa, and 7.09 (95%CI 4.85-10.36) for stage IVb. A similar gradual increase in risk was noted for the N classification. For the T classification, however, there was a less clear variation in risk between T3 and T4. AJCC8 provides a good risk stratification for OSCC. Future research should examine the proposals introduced in the published studies to further improve the performance of AJCC8. en
dc.format.extent 16
dc.language.iso eng
dc.relation.ispartof Head & Neck
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject eighth edition American Joint Committee on Cancer (AJCC 8)
dc.subject depth of invasion (DOI)
dc.subject extranodal extension
dc.subject N classification
dc.subject oral squamous cell carcinoma (OSCC)
dc.subject prognosis
dc.subject T classification
dc.subject TNM stage
dc.subject WORST PATTERN
dc.subject LYMPH-NODES
dc.subject EDITION
dc.subject TONGUE
dc.subject INVASION
dc.subject DEPTH
dc.subject 7TH
dc.subject HEAD
dc.subject VALIDATION
dc.subject PROGNOSIS
dc.subject 111 Mathematics
dc.subject 3125 Otorhinolaryngology, ophthalmology
dc.title Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer : Systematic review and meta-analysis en
dc.type Review Article
dc.contributor.organization HUS Head and Neck Center
dc.contributor.organization Department of Pathology
dc.contributor.organization Research Program in Systems Oncology
dc.contributor.organization Centre of Excellence in Complex Disease Genetics
dc.contributor.organization Statistical and population genetics
dc.contributor.organization Department of Mathematics and Statistics
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Biostatistics Helsinki
dc.contributor.organization Department of Public Health
dc.contributor.organization Department of Ophthalmology and Otorhinolaryngology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1002/hed.26344
dc.relation.issn 1043-3074
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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