The association of endothelial injury and systemic inflammation with perioperative myocardial infarction

Show full item record



Permalink

http://hdl.handle.net/10138/319730

Citation

Ollila , A , Vikatmaa , L , Virolainen , J , Nisula , S , Lakkisto , P , Vikatmaa , P , Tikkanen , I , Venermo , M & Pettila , V 2019 , ' The association of endothelial injury and systemic inflammation with perioperative myocardial infarction ' , Annals of Clinical Biochemistry , vol. 56 , no. 6 , 0004563219873357 , pp. 674-683 . https://doi.org/10.1177/0004563219873357

Title: The association of endothelial injury and systemic inflammation with perioperative myocardial infarction
Author: Ollila, Aino; Vikatmaa, Leena; Virolainen, Juha; Nisula, Sara; Lakkisto, Paivi; Vikatmaa, Pirkka; Tikkanen, Ilkka; Venermo, Maarit; Pettila, Ville
Contributor organization: Anestesiologian yksikkö
Department of Diagnostics and Therapeutics
Clinicum
HUS Perioperative, Intensive Care and Pain Medicine
Helsinki University Hospital Area
HUS Heart and Lung Center
Kardiologian yksikkö
Department of Medicine
HUSLAB
Department of Clinical Chemistry and Hematology
Medicum
HUS Abdominal Center
Verisuonikirurgian yksikkö
Nefrologian yksikkö
Department of Surgery
Date: 2019-11
Language: eng
Number of pages: 10
Belongs to series: Annals of Clinical Biochemistry
ISSN: 0004-5632
DOI: https://doi.org/10.1177/0004563219873357
URI: http://hdl.handle.net/10138/319730
Abstract: Background Major surgery predisposes to endothelial glycocalyx injury. Endothelial glycocalyx injury associates with cardiac morbidity, including spontaneous myocardial infarction. However, the relation between endothelial glycocalyx injury and the development of perioperative myocardial infarction remains unknown. Methods Fifteen perioperative myocardial infarction patients and 60 propensity-matched controls were investigated in this prospective study. The diagnosis of perioperative myocardial infarction was based on repeated cardiac troponin T measurements, electrocardiographs and recordings of ischaemic signs and symptoms. We measured endothelial glycocalyx markers - soluble thrombomodulin, syndecan-1 and vascular adhesion protein 1 - and an inflammatory marker, namely interleukin-6, preoperatively and 6 h and 24 h postoperatively. We calculated the areas under the receiver operating characteristics curves (AUCs) to compare the performances of the different markers in predicting perioperative myocardial infarction. The highest value of each marker was used in the analysis. Results The interleukin-6 concentrations of perioperative myocardial infarction patients were significantly higher preoperatively and 6 and 24 h postoperatively (P = 0.002, P = 0.002 and P = 0.001, respectively). The AUCs (95% confidence intervals) for the detection of perioperative myocardial infarction were 0.51 (0.34-0.69) for soluble thrombomodulin, 0.63 (0.47-0.79) for syndecan-1, 0.54 (0.37-0.70) for vascular adhesion protein 1 and 0.69 (0.54-0.85) for interleukin-6. Conclusions Systemic inflammation, reflected by interleukin-6, associates with cardiac troponin T release and perioperative myocardial infarction. Circulating interleukin-6 demonstrated some potential to predict perioperative myocardial infarction, whereas endothelial glycocalyx markers did not.
Subject: Cardiology
analytical systems
proteins
CORONARY RESISTANCE VESSELS
VASCULAR ADHESION PROTEIN-1
NONCARDIAC SURGERY
ANGINA-PECTORIS
GLYCOCALYX
DYSFUNCTION
DISEASE
MORTALITY
EVENTS
DAMAGE
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
The_association_of_endothelial_injury.pdf 728.4Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record