IL-10 to TNF alpha ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses

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Kaislasuo , J , Simpson , S , Petersen , J F , Peng , G , Aldo , P , Lokkegaard , E , Paidas , M , Pal , L , Guller , S & Mor , G 2020 , ' IL-10 to TNF alpha ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses ' , American Journal of Reproductive Immunology , vol. 83 , no. 1 , 13195 . https://doi.org/10.1111/aji.13195

Title: IL-10 to TNF alpha ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses
Author: Kaislasuo, Janina; Simpson, Samantha; Petersen, Jesper F; Peng, Gang; Aldo, Paulomi; Lokkegaard, Ellen; Paidas, Michale; Pal, Lubna; Guller, Seth; Mor, Gil
Contributor: University of Helsinki, HUS Gynecology and Obstetrics
Date: 2020-01
Language: eng
Number of pages: 10
Belongs to series: American Journal of Reproductive Immunology
ISSN: 1046-7408
URI: http://hdl.handle.net/10138/319803
Abstract: Abstract Problem Embryo implantation and placentation require a careful immunological balance. Cytokines such as IL-10 and TNFα have been implicated as markers of dysregulation, but have only been studied at a single time point or after a pregnancy lost. Our objective was to determine normative patterns of serum levels of IL-10 and TNFα and their ratio throughout the first trimester in healthy pregnancies, and to determine if this pattern differs from pregnancy loss. Methods Two prospective longitudinal cohorts of gravidae including in vitro fertilization (IVF) and naturally conceived pregnancies with serial blood draws. Cytokines were assayed using SimplePlex. In the IVF cohort we monitored from the implantation day up to 6 weeks of gestation; whereas in the naturally conceived cohort, sample collection began at 4 weeks and throughout the whole first trimester. Results IL-10 concentrations in normal pregnancies were significantly higher than in pregnancies ending in a loss starting at 6-8 weeks of gestation while TNFα concentrations were significantly lower in normal than in pregnancies ending in a loss starting at 3-5 of gestation weeks. The IL-10 to TNFα ratio in normal pregnancies was significantly higher from 4 to 9 weeks compared to pregnancies that were lost (t-test, p
Subject: embryo implantation
infertility
inflammation
interleukin-10
pregnancy loss
TNFα
CYTOKINES
TNF alpha
MISCARRIAGE
WOMEN
IMMUNE-SYSTEM
INFLAMMATION
EXPRESSION
3123 Gynaecology and paediatrics
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