Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer

Show full item record



Permalink

http://hdl.handle.net/10138/320166

Citation

Almangush , A , Mäkitie , A A , Hagström , J , Haglund , C , Kowalski , L P , Nieminen , P , Coletta , R D , Salo , T & Leivo , I 2020 , ' Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer ' , BMC Cancer , vol. 20 , no. 1 , 843 . https://doi.org/10.1186/s12885-020-07342-x

Title: Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer
Author: Almangush, Alhadi; Mäkitie, Antti A.; Hagström, Jaana; Haglund, Caj; Kowalski, Luiz Paulo; Nieminen, Pentti; Coletta, Ricardo D.; Salo, Tuula; Leivo, Ilmo
Contributor organization: HUS Head and Neck Center
Department of Pathology
University of Helsinki
Research Program in Systems Oncology
Faculty of Medicine
Department of Oral and Maxillofacial Diseases
Department of Ophthalmology and Otorhinolaryngology
Helsinki University Hospital Area
Medicum
CAN-PRO - Translational Cancer Medicine Program
Research Programs Unit
HUS Abdominal Center
II kirurgian klinikka
Department of Surgery
Clinicum
HUSLAB
Date: 2020-09-03
Language: eng
Number of pages: 7
Belongs to series: BMC Cancer
ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-020-07342-x
URI: http://hdl.handle.net/10138/320166
Abstract: BackgroundCell-in-cell structures (caused by cell cannibalistic activity) have been related to prognosis of many cancers. This is the first multi-institutional study to assess the prognostic impact of cell-in-cell structures in a large cohort of early oral tongue squamous cell carcinomas (OTSCC).MethodsA total of 308 cases from five Finnish University Hospitals and from the A.C. Camargo Cancer Center, SAo Paulo, Brazil, were included in this study. Cell-in-cell structures were evaluated on surgical postoperative sections that stained with hematoxylin and eosin staining.ResultsWe found that cell-in-cell structures associated with cancer-related mortality in univariable analysis with a hazard ratio (HR) of 2.99 (95%CI 1.52-5.88; P=0.001). This association was confirmed in multivariable analysis (HR 2.22, 95%CI 1.12-4.44; P=0.024). In addition, statistically significant associations were observed between the cell-in-cell structures and other adverse histopathologic characteristics including deep invasion (P<0.001), high index of tumor budding (P=0.007), worst pattern of invasion (P<0.001), perineural invasion (P=0.01), and stroma-rich pattern (P=0.001).ConclusionsOur findings demonstrate a significant relationship between cell-in-cell formation and aggressive characteristics of early OTSCC. Cell-in-cell structures have a distinct impact as a novel prognostic indicator in early OTSCC and they can be easily assessed during routine pathology practice.
Subject: Cell-in-cell formation
Tongue neoplasms
Biomarkers
Mortality
CANNIBALISM
ENTOSIS
PREDICTION
CARCINOMA
CAVITY
3122 Cancers
3125 Otorhinolaryngology, ophthalmology
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
document_1.pdf 1.085Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record