Recent advances in the understanding of trimeric autotransporter adhesins

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Kiessling , A R , Malik , A & Goldman , A 2020 , ' Recent advances in the understanding of trimeric autotransporter adhesins ' , Medical Microbiology and Immunology , vol. 209 , no. 3 , pp. 233-242 . https://doi.org/10.1007/s00430-019-00652-3

Title: Recent advances in the understanding of trimeric autotransporter adhesins
Author: Kiessling, Andreas R.; Malik, Anchal; Goldman, Adrian
Other contributor: University of Helsinki, Molecular and Integrative Biosciences Research Programme


Date: 2020-06
Language: eng
Number of pages: 10
Belongs to series: Medical Microbiology and Immunology
ISSN: 0300-8584
DOI: https://doi.org/10.1007/s00430-019-00652-3
URI: http://hdl.handle.net/10138/320221
Abstract: Adhesion is the initial step in the infection process of gram-negative bacteria. It is usually followed by the formation of biofilms that serve as a hub for further spread of the infection. Type V secretion systems engage in this process by binding to components of the extracellular matrix, which is the first step in the infection process. At the same time they provide protection from the immune system by either binding components of the innate immune system or by establishing a physical layer against aggressors. Trimeric autotransporter adhesins (TAAs) are of particular interest in this family of proteins as they possess a unique structural composition which arises from constraints during translocation. The sequence of individual domains can vary dramatically while the overall structure can be very similar to one another. This patchwork approach allows researchers to draw conclusions of the underlying function of a specific domain in a structure-based approach which underscores the importance of solving structures of yet uncharacterized TAAs and their individual domains to estimate the full extent of functions of the protein a priori. Here, we describe recent advances in understanding the translocation process of TAAs and give an overview of structural motifs that are unique to this class of proteins. The role of BpaC in the infection process of Burkholderia pseudomallei is highlighted as an exceptional example of a TAA being at the centre of infection initiation.
Subject: Trimeric autotransporter adhesins (TAAs)
Autotransporter
Protein secretion
Adhesins
Burkholderia pseudomallei
BpaC
Protein translocation
Protein export
BAM
Gram-negative bacteria
Autotransport
Outer membrane
Transmembrane beta-barrel
Type V secretion
Bacterial proteins
Bacterial outer membrane proteins
Protein folding
Protein structure
Protein transport
Virulence factors
chemistry
GRAM-NEGATIVE BACTERIA
BARREL ASSEMBLY MACHINERY
MORAXELLA-CATARRHALIS
PROTEIN SECRETION
BURKHOLDERIA-PSEUDOMALLEI
YERSINIA-ENTEROCOLITICA
BARTONELLA-HENSELAE
PASSENGER DOMAIN
TRANSPORT
TRANSLOCATION
11832 Microbiology and virology
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