RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer

Show full item record



Permalink

http://hdl.handle.net/10138/320237

Citation

Mahato, A.K.; Sidorova, Y.A. RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer. Int. J. Mol. Sci. 2020, 21, 7108.

Title: RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer
Author: Mahato, Arun Kumar; Sidorova, Yulia A.
Publisher: Multidisciplinary Digital Publishing Institute
Date: 2020-09-26
URI: http://hdl.handle.net/10138/320237
Abstract: Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal circumstances interacts with ligand at the cell surface and mediates various essential roles in a variety of cellular processes such as proliferation, differentiation, survival, migration, and metabolism. RET plays a pivotal role in the development of both peripheral and central nervous systems. RET is expressed from early stages of embryogenesis and remains expressed throughout all life stages. Mutations either activating or inhibiting RET result in several aggressive diseases, namely cancer and Hirschsprung disease. However, the physiological ligand-dependent activation of RET receptor is important for the survival and maintenance of several neuronal populations, appetite, and weight gain control, thus providing an opportunity for the development of disease-modifying therapeutics against neurodegeneration and obesity. In this review, we describe the structure of RET, its signaling, and its role in both normal conditions as well as in several disorders. We highlight the differences in the signaling and outcomes of constitutive and ligand-induced RET activation. Finally, we review the data on recently developed small molecular weight RET agonists and their potential for the treatment of various diseases.


Files in this item

Total number of downloads: Loading...

Files Size Format View
ijms-21-07108.pdf 933.8Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record