Natural products as modulators of eukaryotic protein secretion

Show full item record



Permalink

http://hdl.handle.net/10138/320286

Citation

Luesch , H & Paavilainen , V O 2020 , ' Natural products as modulators of eukaryotic protein secretion ' , Natural Product Reports , vol. 37 , no. 5 , pp. 717-736 . https://doi.org/10.1039/c9np00066f

Title: Natural products as modulators of eukaryotic protein secretion
Author: Luesch, Hendrik; Paavilainen, Ville O.
Other contributor: University of Helsinki, Institute of Biotechnology

Date: 2020-05-01
Language: eng
Number of pages: 20
Belongs to series: Natural Product Reports
ISSN: 0265-0568
DOI: https://doi.org/10.1039/c9np00066f
URI: http://hdl.handle.net/10138/320286
Abstract: Covering: up to the end of 2019 Diverse natural product small molecules have allowed critical insights into processes that govern eukaryotic cells' ability to secrete cytosolically synthesized secretory proteins into their surroundings or to insert newly synthesized integral membrane proteins into the lipid bilayer of the endoplasmic reticulum. In addition, many components of the endoplasmic reticulum, required for protein homeostasis or other processes such as lipid metabolism or maintenance of calcium homeostasis, are being investigated for their potential in modulating human disease conditions such as cancer, neurodegenerative conditions and diabetes. In this review, we cover recent findings up to the end of 2019 on natural products that influence protein secretion or impact ER protein homeostasis, and serve as powerful chemical tools to understand protein flux through the mammalian secretory pathway and as leads for the discovery of new therapeutics.
Subject: NUCLEOTIDE-EXCHANGE FACTORS
INDUCED XBP1 ACTIVATION
PROSTATIC-CANCER CELLS
ENDOPLASMIC-RETICULUM
ER STRESS
BIOLOGICAL EVALUATION
BREFELDIN-A
THAPSIA-GARGANICA
TARGET IDENTIFICATION
IPOMOEA-SQUAMOSA
1182 Biochemistry, cell and molecular biology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
c9np00066f.pdf 2.515Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record